Sentences with phrase «significantly suppressed»

The extract was tested on human cells, and the generation of reactive oxygen species (free radicals) by immune system actors was significantly suppressed.

Nowadays there also seem to be positive effects of phytic acid: it inhibits temporarily the enzyme amylase and therefore the conversion of starch to sugar and the rise of the blood glucose level can be significantly suppressed.

And, when quercetin was given orally, it significantly suppressed pancreatic tumor growth in live animals.

A tissue culture study published in the «Journal of Medicinal Food» found that dandelion greens significantly suppressed nitric oxide, prostaglandins and cytokines — all known as pro-inflammatory molecules.

Animal research, for example, indicated that supplementing with probiotics significantly suppressed changes in water loss, skin hydration, and skin thickening in response to UVB radiation, and also reduced skin damage.

Expression of both NANOG and MDR1 was significantly suppressed by treatment with the MIA - 602 / doxorubicin combination compared to MIA - 602 or doxorubicin alone in A.

The genes MDR1 and NANOG, both involved in the regulation and expression of efflux pump mechanisms, were significantly suppressed.

Plerixafor in combination with the chemotherapeutic agent dacarbazine significantly suppressed the metastatic phenotype of melanoma compared to dacarbazine alone [40].

Indeed, we found that ectopic expression of miR - 7 significantly suppressed the ability of sphere formation of MCF7BoM cells, whereas miR7 - specific LNA enhanced the sphere - forming ability (Fig. 1E).

As shown in Fig. 2B, we found that both miR -7-1 and miR -7-2 significantly suppressed the expression of KLF4 in these cells, and the similar suppressive effect of miR - 7 was observed when we used CN34BoM, CN34BrM, and MCF7BoM cells.

Interestingly, high expression of KLF4 was significantly and inversely correlated to brain but not bone metastasis - free survival of patients with breast cancer, and we indeed found that the expression of miR - 7 significantly suppressed the ability of CSCs to metastasize to brain but not to bone in our animal model.

As shown in Fig. 2D, the reporter activity of 3 ′ UTR of KLF4 was significantly suppressed by miR - 7, whereas cotransfection of LNA targeting miR - 7 stimulated the expression of this gene.

Among their findings: in streams with the amphetamine addition, the growth of biofilms was significantly suppressed, the composition of bacterial and diatom communities changed, and aquatic insects emerged earlier.

While the new mosquitoes significantly suppressed dengue virus infection they did not show any resistance to Zika or chikungunya, two other viruses carried by Aedes aegypti.

Further, such treatment significantly suppressed tumor growth in mice.

As the mean temperature rises, for instance, wage growth is significantly suppressed, said Goetz, who also worked with and Jiaochen Liang, assistant professor of agricultural business, California State University, Fresno.

And by the way, how can a successful dollar Eurobond priced at over 7 % be the evidence anyone offers when FDI and portfolio investment remain significantly suppressed in the economy?

and «how can a successful dollar Eurobond priced at over 7 % be the evidence anyone offers when FDI and portfolio investment remain significantly suppressed in the economy?».

But by combining the drug with a PGAM1 inhibitor to impair both homologous recombination and PARP - dependent DNA repair, the researchers were able to significantly suppress tumor growth.

They found the bismuth - based metallodrug to effectively paralyze multi-resistant superbugs, e.g. Carbapenem - resistant Enterobacteriaceae (CRE) and Carbapenem - resistant Klebsiella pneumoniae (CRKP) and significantly suppress the development of antibiotic resistance, allowing the lifespan of currently - used antibiotic to be largely extended.

Finally, iPSC - NK cells were assessed using the same model, which found that CD4ζ - iPSC -, and iPSC - NK cells were able to maintain CD4 + T - cell number and significantly suppress viral load in the peripheral blood compared to controls.

CB1 antagonists have been shown to decrease nicotine self - administration in rodent models of nicotine dependence.24 While CB1 agonists increase feeding in rats and humans, CB1 antagonists have been shown to have the opposite effect, significantly suppressing rats» food intake regardless of type of diet (standard lab chow, high fat or high carbohydrate).

One tablespoon of flaxseeds was found to significantly suppress appetite and calorie intake.

(They've also been found to significantly suppress appetite and calorie intake!)

If the cost of insuring you is too high, then this overhead will significantly suppress your cash growth.

Not exact matches

The research shows that the drug, CS - 104, suppresses the normal biological response to UVB burning most significantly when applied within five minutes of the injury.

Researchers from the University of Michigan, Wayne State University and Friedrich Miescher Institute for Biomedical Research in Switzerland found that suppressing the animal's ability to taste its food - regardless of how much it actually eats — can significantly increase or decrease its length of life and potentially promote healthy aging.

Figure on the right: Bortezomib treatment is significantly less effective in multiple myeloma patients who have suppressed expression of a 19s proteasome cap subunit.

The study found topical administration of Vinpocetine suppressed inflammation and the overproduction of mucus induced by Streptococcus pneumonia bacteria, improved hearing loss in the middle ear and significantly improved bacterial clearance in animal studies.

When a strain of mice genetically destined to develop a form of TLR7 - dependent lupus was crossbred with a strain in which TREML4 expression was suppressed, offspring lacking TREML4 were protected from the development of lupus - associated kidney failure and had significantly lower blood levels of inflammatory factors and autoantibodies than did mice expressing TREML4.

All six significantly inhibited growth of the fungus, and two isolates performed especially well in suppressing fungal growth for more than 35 days.

«Clarifying the mechanism for suppressing turbulence through ion mass: Theoretical research develops significantly towards improved performance in fusion plasmas.»

The inflammation parameters in the transplanted kidneys decreased significantly and renal function in all recipients is excellent,» summarises Marcus Groettrup, adding that these results suggest immunoproteasome inhibition as a promising therapeutic approach to suppress chronic antibody - mediated rejection.

But because both drugs suppress hormone production, he said the study presents «proof of principle» that combining hormonal therapy with radiation treatment significantly reduces the rate of metastases and death in the patient group studied.

As shown in Fig. 4B, suppressive ability of miR - 7 on both transmigration through endothelial cells and Matrigel was significantly attenuated by ectopic expression of KLF4, suggesting that miR - 7 suppresses invasive ability of CSCs by blocking KLF4 expression.

On the other hand, animals that received CSCs carrying miR -7-2 showed significantly less signals in the brain, suggesting that miR -7-2 was indeed capable of suppressing brain metastasis of CSCs (Fig. 3B and C).

Survival was longer and there was a significantly lower number of MDSCs, which also had lower ability to suppress T cells, thus suggesting that soluble antibodies are responsible for accumulation of immune suppressive MDSCs.

Combining a cancer therapy with a second drug therapy that helps suppress tumour blood vessels found in cancer cells can help to significantly reduce the spread of breast cancer tumours while also causing cancer cell death.

In normal puberty, growth velocity is high, GH is often not suppressed on OGTT, and pituitary volume increases significantly (more prominent in girls)(33); therefore, assessing adolescent AIP mutation carriers may present a particular diagnostic difficulty.

When TRIP - Br2 is suppressed, the expression of hormone sensitive lipase (HSL) and Beta3 - adrenergic (Adrb3) receptors, which are involved in fat breakdown (lipolysis), is significantly enhanced in fat tissue.

Analysis of NANOG indicates that the combination treatment suppresses expression significantly (P < 0.001) more than either compound alone (figure 3a).

The combination also significantly (P < 0.05) suppressed the expression of MDR1 and NANOG genes compared to doxorubicin alone, which did not have a significant effect (figure 3b).

I also had Hashimoto's, which caused my prolactin levels to be suppressed significantly enough to prevent me from breastfeeding.

Did you know there is a tremendous amount of little known (suppressed) scientific research proving that woman can significantly reduce their risk of breast cancer and many other chronic diseases through natural therapies?

Switching people to a plant - based diet can significantly lower IGF - 1 levels within just 11 days, markedly improving the ability of women's bloodstreams to suppress breast cancer growth, and then kill breast cancer cells off.

This lowering of IGF - 1 levels is thought to be why the blood of men and women eating plant - based diets suppresses prostate and breast cancer growth in vitro significantly better than those eating the Standard American Diet.

An elevated leptin also indicates, however, that the TSH is an unreliable marker for tissue thyroid levels, as the TSH is often suppressed, along with significantly reduced T4 - to - T3 conversion.

Whey protein significantly increased an appetite - controlling hormone called glucagon - like peptide - 1 and suppressed the desire to eat, according to the study.

In contrast, testosterone levels that become too high significantly increase corticosterone levels, which suppress immune activity.

Now, just - published research supports the ability of quercetin — a plant compound — to not only suppress the growth of pancreatic cancer cells, but to help significantly reduce the risk of developing the disease in the first place.