The clinic routinely looks for
signs of all amyloid proteins in these brains to distinguish prion disease from other conditions.
Out of all the research participants, 139 showed
no sign of amyloid proteins associated with preclinical Alzheimer's.
Not exact matches
The brains
of people with Alzheimer's show several
signs of the disease: plaques made
of a
protein called
amyloid - β, tangles
of a
protein called tau and the loss
of neurons.
Scientists have long considered clumps
of amyloid plaques — sticky, barnacle - like
protein bundles — to be the first
sign of Alzheimer's.
Spinal fluid analyses and positron emission tomography (PET) scans can detect a key warning
sign — buildup
of amyloid - beta
protein in the brain.
Two participants had remarkably clean brains with few
signs of amyloid - beta plaques and tangles
of tau
protein.
The accumulation
of the
protein amyloid beta in the brain is a
sign of Alzheimer's disease.
Interestingly, most
of the people showing the
amyloid deposits in their brains did not also have the other hallmark
sign of Alzheimer's, the fibrous tangles
of the tau
protein.