Sentences with phrase «silence key genes»

Not exact matches

A study in this week's Neuron provides key evidence that DNA methylation — also known to occur as cancerous cells divide, when tumor suppressor genes are silenced — occurs in adult brains and can be triggered by environmental cues.

Hypermethylation of DNA is a key epigenetic mechanism for the silencing of many genes, including those for cell cycle regulation, receptors, DNA repair, and apoptosis (5, 6, 7, 8).

We are focusing on a few key molecular pathways including; 1) Polycomb - mediated epigenetic gene silencing in the tumor initiation, maintenance, and invasion, 2) c - Met (receptor tyrosine kinase) signal transduction pathways in stemness and migration of these tumor cells, 3) Novel mitogenic signaling pathways that are specific to GSCs, and 4) Identification of radio - and chemo - sensitizing pathway to maximize therapeutic efficacy.

These two histones thus have a key role of epigenetic silencing of tumor suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets.

Epigenetics Dream Team leaders have identified an epigenetic process, known as DNA de-methylation, that inactivates or «silences» key genes that might otherwise correct for the «mistakes» that permit cancer to exist and flourish.

Background: Small non-coding RNAs, including miRNAs, and gene silencing mediated by RNA interference have been described in free - living and parasitic lineages of flatworms, but only few key factors of the small RNA pathways have been exhaustively investigated in a limited number of species.

Arognaute plays a key role in the RNA interference (RNAi) pathway that silences gene expression.

This complex plays a key role in the RNA interference (RNAi) pathway that silences gene expression.