Sentences with phrase «silenced tumor suppressor»
McGarvey, K. M.; Fahrner, J. A.; Greene, E.; Martens, J.; Jenuwein, T.; Baylin, S. B. Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state.
https://www.thesgc.org/
His group uses genome - wide and gene - specific DNA methylation analysis to identify aberrantly silenced tumor suppressor genes in B cell leukemias and lymphomas.
The role of histone codes and DNA methylation in silencing tumor suppressor genes, Cancer Cell 3:89 - 95, 2003.
Not exact matches
«Epigenetic silencing of tumor suppressor promotes endometrial cancer.»
A single addition or subtraction of a few carbon and hydrogen ions can determine the silencing of a tumor suppressor gene or the overexpression of an oncogene.
A study in this week's Neuron provides key evidence that DNA methylation — also known to occur as cancerous cells divide, when tumor suppressor genes are silenced — occurs in adult brains and can be triggered by environmental cues.
On the other hand, our earlier work also showed that this enzyme acts to silence tumor - suppressor genes.
They propose that normal tissue becomes primed for cancer when oncogenes are activated and tumor suppressor genes are silenced or lost, but that cancer develops only when a cell in the tissue reverts to a more primitive, embryonic state and starts dividing.
Many tumor suppressor and receptor genes have been reported to be hypermethylated and transcriptionally silenced during the development of different types of cancers.
Epigenetic silencing of the p16 (INK4a) tumor suppressor is associated with loss of CTCF binding and a chromatin boundary.
These two histones thus have a key role of epigenetic silencing of tumor suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets.
RNA - seq analysis of the tumor cell line revealed a number of silenced genes (presumably including many tumor suppressors).
Lopez - Serra P and Esteller M. DNA - methylation - associated silencing of tumor - suppressor microRNAs in cancer.
Methylation of tumor suppressor genes has been shown by Kimmel Cancer Center investigators to silence them, allowing cancers to start.
Her graduate work culminated in multiple publications in the field of cancer epigenetics and in a thesis entitled «Aberrant epigenetic silencing of tumor suppressor genes in human cancer: the roles of DNA hypermethylation and the histone code.»
In combination with this approach, inhibitors of DNA methylation and / or histone deacetylases are expected to relieve repression of DAPK tumor suppressors, whose epigenetic silencing has emerged as a recurring theme from our work and throughout the literature.
Many phytochemicals can reactivate tumor suppressor genes silenced by epigenetic modifications.