McGarvey, K. M.; Fahrner, J. A.; Greene, E.; Martens, J.; Jenuwein, T.; Baylin, S. B.
Silenced tumor suppressor genes reactivated by DNA demethylation do not return to a fully euchromatic chromatin state.
His group uses genome - wide and gene - specific DNA methylation analysis to identify aberrantly
silenced tumor suppressor genes in B cell leukemias and lymphomas.
The role of histone codes and DNA methylation in
silencing tumor suppressor genes, Cancer Cell 3:89 - 95, 2003.
Not exact matches
A single addition or subtraction of a few carbon and hydrogen ions can determine the
silencing of a
tumor suppressor gene or the overexpression of an oncogene.
A study in this week's Neuron provides key evidence that DNA methylation — also known to occur as cancerous cells divide, when
tumor suppressor genes are
silenced — occurs in adult brains and can be triggered by environmental cues.
On the other hand, our earlier work also showed that this enzyme acts to
silence tumor -
suppressor genes.
They propose that normal tissue becomes primed for cancer when oncogenes are activated and
tumor suppressor genes are
silenced or lost, but that cancer develops only when a cell in the tissue reverts to a more primitive, embryonic state and starts dividing.
Many
tumor suppressor and receptor
genes have been reported to be hypermethylated and transcriptionally
silenced during the development of different types of cancers.
These two histones thus have a key role of epigenetic
silencing of
tumor suppressor genes in breast cancer (and likely other cancers), suggesting that they may represent new therapeutic targets.
RNA - seq analysis of the
tumor cell line revealed a number of
silenced genes (presumably including many
tumor suppressors).
Methylation of
tumor suppressor genes has been shown by Kimmel Cancer Center investigators to
silence them, allowing cancers to start.
Her graduate work culminated in multiple publications in the field of cancer epigenetics and in a thesis entitled «Aberrant epigenetic
silencing of
tumor suppressor genes in human cancer: the roles of DNA hypermethylation and the histone code.»
Many phytochemicals can reactivate
tumor suppressor genes silenced by epigenetic modifications.