Sentences with word «silico»

In addition to presentations on the latest research from the Insigneo Institute, the Showcase will also feature presentations and debates involving some of the most prestigious names in in silico medicine from across the world, including Frederic Turquier (Director, Research and Development, Surgical Innovations, Medtronic); Norbert Graf (Professor in Paediatric Oncology, University of Saarland, Germany); and Peter Varga, (Director, National Center for Spinal Disorders, Budapest, Hungary).

With CiPA, human iPSC - cardiomyocytes are employed to assess drug effects on the cardiac action potential to confirm the outcome of in silico modeling efforts, relying on hiPSC - cardiomyocytes to provide the integrated drug response from multiple native human currents in a human - derived cellular preparation.

Animation showing the same cells in transmitted light (black and white) and fluorescence (colored) imaging, along with predicted fluorescence labels from the in silico labeling model.

Delegates at this year's Insigneo Showcase (May 5, 2016 at The Octagon Centre in Sheffield) will hear how in silico medicine — computer simulations of the human body and its disease processes — can help improve diagnosis and prognosis for conditions like Parkinson's and pulmonary vascular disease.

Due to an increasing number of novel TPs, a risk assessment and prioritization by means of in silico methods becomes more and more indispensable.

Wood takes over from John Baldoni, who is going to be leading a new team for GSK focused on enhancing drug discovery through the use of in silico technology, including artificial intelligence, machine learning and deep learning, GSK tells me.

«Our work in the dogs, in vitro and in silico shows us the consequences of these mutations in disrupting the function of these crucial channels,» said Karina Guziewicz, senior author on the study and a senior research investigator at Penn's School of Veterinary Medicine.

By using a novel in silico screening approach, the researchers were able to identify several fragments with the capacity to bind to MTH1.

Numerate will utilize its proprietary in silico drug design platform, along with its track record of solving the problem of multiple, often competing, objectives of safe and effective drug design.

We combine biochemical, structural, cellular and functional information using purified proteins, mutant and transgenic plants, yeast and chemical genomic screening systems, transient gene expression assays, confocal microscopy and in silico data analysis to compare ROP - centered kinase signaling during cell polarity (in vitro pollen tubes), morphogenesis (whole plant) and pathogenesis (fungi - infected cells).

Next, we use three different approaches to find novel small molecules which are able to bind and inhibit specifically the synthetic lethal protein: 1) lead discovery using in vitro screens, 2) leveraging existing drugs (fallen angels and re-positioning), 3) artificial intelligence based in silico discovery of novel compounds.

Ferrante and Tuci both say they're sure that the physical bots would behave just the same if the in silico environment were replicated in the real world.

There, I performed the spectroscopic analysis of the in silico predicted protein - ligand pairs of endocrine disruptors and breast cancer proteins using circular dichroism, native mass spectrometry and microscale thermophoresis.

Jonathan Lynch, a plant physiologist at The Pennsylvania State University and another founder of the crops in silico movement, looks at root behavior under a range of soil nutrient conditions.

To achieve this later phase, the burgeoning in silico field will need to grow substantially, especially in the U.S. Lynch, who also has a position with the University of Nottingham in England, feels Europe is more willing to invest in crop modeling.

Scientists working on crops in silico anticipate the growing potential of this young field, and what they will learn about foods essential to human survival.

We will have an in silico search for the right combination of different 2D crystals while reducing the need for expensive lab work and test trials.»

To do this, researchers are turning to natural intelligence (NI), which attempts to duplicate in silico what we do naturally in vivo, namely the processing of knowledge in both a deductive and reductive way.

The team is conducting physical experiments to confirm and refine their in silico findings.

This approach allowed for the creation of thousands of in silico datasets to mine for potential biomarkers.

Our work establishes such a technological paradigm shift, proving that nanoscale memristors can indeed be used to formulate in - silico neural circuits for processing big - data in real - time; a key challenge of modern society.

«The next step is to create an in silico plant to virtually simulate the amazingly complex interactions among biological scales,» said U. of I. plant biology professor Amy Marshall - Colon, a co-author on the report.

The Insigneo Institute hosts an annual showcase bringing together some of the world's leading in silico experts, with clinical translation as the theme of this year's event.

-- In silico basic and systems biology: We develop innovative approaches to reverse engineer biological networks from omics data, model tumor progression at the genomic, transcriptomic and epigenetic level, automatically annotate new proteins and functional elements through integration of complex and heterogeneous data, including data obtained from high - throughput sequencing or time - lapse video - microscopy.

Notably, we studied the feasibility for enrichment of ctDNA by physical and in silico size selection in plasma samples collected in 51 patients from multiple cancer types.

Debra O. Prosser, Rongying Tang, Donald R. Love evaluate the sensitivity and specificity of four in silico programmes in predicting the effect of each variant on splicing.

We also develop in silico chemogenomic approaches to analyze jointly the chemical space of small molecules and biological space of protein targets, leading in particular to efficacy profile and secondary effect prediction.

I got a new laboratory of research in bioinformatics and computational chemistry, in which we develop mostly studies in drug design and in silico evaluation of environmental pollutants, and I also proposed a new master program in Bioinformatics.

Research Paper In - silico Designing and Testing of Primers for Sanger Genome Sequencing of Dengue Virus Types of Asian Origin Ajay Prakash Joshi, Annette Angel, Bennet Angel, Rajendra Kumar Baharia, Suman Rathore, Neha Sharma, Karuna Yadav, Sharad Thanvi, Indu Thanvi, Vinod Joshi J. Genomics 2018; 6: 34 - 40.

We conclude by indicating future research in this area which combines both in - vitro and in silico work.

All labs stress the modern synthesis of molecular biology and computation, integrating in vitro experimentation with in silico bioinformatics.

In silico clustering and normalization of the messenger RNA tags yielded 1,463 robust clusters from 829 different brain transcripts.

JCVI's training philosophy revolves around a mix of not only lecture - based seminars, but also hands - on training in both the wet lab and in silico computational environments.

Within silico, a computational neural model was made to predict neural activity in slow - wave sleep.