Interestingly, when mouse neural precursor cells were examined for
similar Cohesin / CTCF - bound loops, not only did the cells have such loops, but they were in similar locations as in the ESC genome.
«Now, through our new study, we show that lowering levels of a particular
cohesin protein called Rad21 in embryonic zebrafish produces
similar types of heart defects to those found in people with CdLS,» Associate Professor Horsfield says.