Sentences with phrase «similar aged mouse»

Not exact matches

Similar research since has found what may be the genetic signatures of Norwegian Viking Age mice in modern populations on the Azores, an island chain more than 900 miles west of Portugal.

Fossils of the other new species, found in rocks of a similar age a few dozen kilometers away, suggest that creature — dubbed Vilevolodon, roughly from the Latin for «toothed glider» — was about as large as a midsized mouse.

Similar to humans, the aged mice exhibited enlarged hearts, a general thickening of the heart wall and a reduced efficiency in the hearts ability to pump blood.

The new drug, in its time - release coating, was tested in mice with abnormalities similar to those experienced by people with neovascular age - related macular degeneration, or «wet» AMD.

Although we did observe positive effects on some aging traits, such as memory impairments and reduced red blood cell counts, our studies showed that similar drug effects are also seen in young mice, indicating that rapamycin did not influence these measures by slowing aging, but rather via other, aging - independent, mechanisms.»

But she notes that studies in young knock - out mice may not predict the helpfulness of PlGF and similar molecules in healing fractures in humans of all ages.

Conversely, Tg - hIAPP mice inoculated with WT pancreas homogenate (hereafter referred to as the Tg / WT group) only began to show small IAPP aggregates at around 20 wk of age (Fig. 3, A and B), in a manner similar to untreated Tg mice.

The researchers also did functional MRI (fMRI) studies of the mice with inhibited RbAp48 and found a selective effect in the DG, similar to that seen in fMRI studies of aged mice, monkeys, and humans.

This effect of RbAp48 inhibition on the DG was accompanied by defects in molecular mechanisms similar to those found in aged mice.

Further analysis revealed that the mice in Tg / Tg group, which developed severe hyperglycemia, lost > 75 % of their β cells compared with WT mice of the same strain and similar age.

Because patients with TTD, XPCS, and CS (but not XP) and the corresponding mouse models share similar accelerated progeroid symptoms [12,13,15,23], we next addressed ageing - related parameters in compound heterozygous mice (Figure 3).

Treatment with AFF 1 or vehicle control was initiated in mThy1 - AS mice at age 3 mo, when early sensorimotor deficits first appear — similar to the target population for the first rollout of the human vaccine.

[19] In the current study, [15] PDGF - AS mice exhibited an increased number and intensity of areas staining for reactive microglia (using Iba1) and astroglia (using GFAP), but vaccination with AFF 1 prevented nearly all of this disease - associated excess, with treated animals exhibiting only the burden of reactive glia present in similar - aged WT mice.

Currently, Everon is optimizing several lead compounds: small molecules and biologics that have already demonstrated a rejuvenation effect in aging animals, as measured by a lowered mouse FI (similar FI has recently been accepted by FDA as a measure of aging in the ongoing Metformin human trial).

Beyond that, Dr. Andersen has shown in unpublished work (presented at the 2014 Rejuvenation Biotechnology Conference8) that eliminating senescent astrocytes confers similar benefits to mice with a model of PD that more closely mimics the fundamental processes that drive Parkinson's in aging people not suffering from either environmental toxicity or rare, genetic causes of PD.

Disease progression was compared in three knockin mouse lines with similar CAG repeat expansion lengths of approximately 190 repeats, were compared at 2, 4, 6 and 10 months of age utilizing PsychoGenics proprietary cubes platform technologies: PhenoCube ®, Smart Cube ® and Neurocube ® as well as standard behavioral testing paradigms including Open Field and Tapered Balance Beam.

Another recent study from Xiao - Jiang Li's laboratory at Emory University used a similar (but not exactly the same) technique to remove huntingtin in mice at 2, 4, and 8 months of age.

We tested this hypothesis by crossing DJ -1-deficient mice with mice that have similar amounts of mtDNA damage in their SNpc as aged humans (Polg mutator mice).

The lack of effect of exercise on progranulin in older mice is similar to the pattern of exercise effects on hippocampal BDNF, which also decrease with age (Adlard et al., 2005a; van Praag et al., 2005).

Previous studies have shown that aged Polg mutator mice accumulate SNpc mtDNA deletions to a similar extent as that found in the SNpc in both PD patients and aged neurologically normal controls (∼ 50 % of mtDNA molecules harboring deletions)(Bender et al., 2006; Kraytsberg et al., 2006; Perier et al., 2013).