Sentences with phrase «similar constitutive»

Compliance programs need to be expanded to cover the additional listed offences, as well as to capture offences committed abroad in countries, which have «similar constitutive elements,» whatever that may mean.

Unfortunately PWGCS has provided no guidance as to when or how it will determine whether a foreign offence has «similar constitutive elements» to the offences listed.

Not exact matches

The constitutive expression of these endothelial cell adhesion molecules was very similar for most of the lines derived from different organs, i.e., very low expression levels of E-selectin and VCAM - 1 and more pronounced expression of ICAM - 1.

Similar conclusions have been reached by other investigators (32) after comparing the levels of constitutive apoptosis in thymic lymphomas of ATM - deficient mice versus ATM / p21 - deficient mice.

A similar situation was apparent at the 5» - UTR of the U2af1 - rs1 gene where constitutive HS were detected on the unmethylated paternal chromosome only.

In 2005, the identification of an activating mutation in JAK2 (the V617F mutation) as a STAT5 - activating and disease - causing genetic alteration in a significant proportion of patients with myeloproliferative neoplasms (MPNs) has emphasized the oncogenic role of the JAK tyrosine kinases in hematologic malignancies.2 — 5 JAK2 is a member of the Janus tyrosine kinase family comprising three other mammalian non-receptor tyrosine kinases (JAK1, JAK3 and TYK2) that associate with cytokine receptors lacking intrinsic kinase activity to mediate cytokine - induced signal transduction and activation of STAT transcription factors.6 All JAKs share a similar protein structure and contain a tyrosine kinase domain at the C - terminus flanked by a catalytically inactive pseudokinase domain with kinase - regulatory activity, by an atypical SH2 domain and by a FERM domain that mediates association to the membrane - proximal region of the cytokine receptors.7, 8 Soon after the discovery of JAK2 V617F, we and others described that activating JAK1 mutations are relatively common in adult patients with T - cell acute lymphoblastic leukemia (ALL) and participate in ALL development allowing for constitutive activation of STAT5.9 — 11 Several STAT5 - activating JAK1 mutations were also reported in AML and breast cancer patients.10

We previously showed that progression of BaF3 phe116 / 9 cells toward cytokine - independence was associated with constitutive activation of JAK1 and STAT5.14 We, therefore, examined whether all JAK1 - mutated autonomous clones (BaF3 Aut) showed a similar signaling profile.

The common life initially rests on the constitutive need for the human beings to be combined to form a community of similar which is also a community of destiny, out of which, as Aristotle wrote it,

The common life initially rests on the constitutive need for the human beings to be combined to form a community of similar which is also a community of destiny, out of which, as Aristotle wrote it, no man could exist humanly, nor simply to survive.