We believe that
a similar early precursor may exist to the PrEc lineage (Figure 9), and while we have no direct evidence for this, we did observe Oct4 positive cells that neither expressed Nanog nor the Venus transgene and there also appears a slight enrichment of early neural markers in the V − S + population (Figure 4).
Not exact matches
According to Prof. Holstein, the leading hypothesis assumes that they originated from organelles of
similar construction and function in unicellular organisms that were absorbed as symbionts by
early precursors of cnidarians.
A detailed comparison of gene expression signatures between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with
early T - cell
precursors, as might have been expected, but more
similar to the expression profile of normal hematopoietic stem cells and granulocyte macrophage
precursors.
On a lighter note, if you wan na go back further than Demon's Souls, the King's Field series was an
earlier precursor to the Souls games, with many
similar elements, though admittedly in a much simpler form.