This new research tool (Figure 2) allows for the rapid analysis of biological specimens (serum, plasma, CSF, etc.) for high - throughput discovery of biomarkers that may be able to discriminate between these two very
similar flaviviruses in a larger window after initial infection than currently possible.
Given the concerns for immune enhancement with other
similar flaviviruses, like yellow fever and Japanese encephalitis, ZPIV will be tested in some volunteers who will first be vaccinated against one of these other flaviviruses.
Not exact matches
The researchers think it likely that other viruses may also target peroxisomes in a
similar manner to
flaviviruses.
Unfortunately, many other viruses from the same family, known as
flaviviruses, have
similar versions of NS1 and can produce a false positive.
His group, led by first author and Heidelberg postdoctoral fellow Mirko Cortese, also found that Zika and dengue, both
flaviviruses, use
similar strategies to infect host cells.
The structure of mature Zika virus is
similar to other
flaviviruses, except in the region of a potential cell attachment site.
The structure is mainly
similar to that of other
flaviviruses such as dengue virus; however, there are differences in a region that may be involved in binding to host receptors.
The high - resolution structure of the Zika virus showed that the overall virus architecture is
similar to other
flaviviruses such as the West Nile and dengue viruses.
The structure of Zika virus is
similar to other known
flavivirus structures, except for the ~ 10 amino acids that surround the Asn154 glycosylation site in each of the 180 envelope glycoproteins that make up the icosahedral shell.
Zika's surface protein — the primary target of antibodies — looks extremely
similar to those on dengue and West Nile virus, members of the same
flavivirus family.
A near - atomic level map of Zika virus shows its structure to be largely
similar to that of dengue virus and other
flaviviruses, but with a notable difference in one key surface protein, report scientists funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Zika is
similar to other members of its viral family, the
flaviviruses.
So far there are no reports of the Zika virus entering the U.S. blood supply, but the FDA writes that «the risk of blood transmission is considered likely based on the most current scientific evidence of how Zika virus and
similar viruses (
flaviviruses) are spread and recent reports of transfusion - associated infection outside of the U.S.»