Sentences with phrase «similar gene expressions»

Using Epiviz and Bioconductor, the research team found consistent regions of DNA methylation changes in colon cancer samples generated by the public Cancer Genome Atlas project and similar gene expression in these regions of DNA methylation changes in other cancer types.

Comparison of the transcripts revealed that breast cancer cells with knockdown of ABL2 alone shared a similar gene expression pattern with that of the ABL1 / ABL2 double - knockdown cells (Fig. 6A and fig.

For example, Urban's group is using another publicly available resource, the Allen Brain Atlas, to find whether groups of neurons with similar electrical function have similar gene expression.

A recent study showed exposure flu viruses among women during pregnancy provoke a similar gene expression pattern in the fetus as that seen in autistic children.

Not exact matches

The resulting transcriptional profiles cluster not by postpartum day, but by milk Na: K ratio, indicating that women sampled during similar postpartum time frames could be at markedly different stages of gene expression.

By day 34 of development, however, the pattern of gene expression was much more similar to control cows derived from artificial insemination, suggesting that these surviving clones were able to implant in the uterus and begin to form a placenta.

At a 0.2 - millimolar sucralose dose similar to the concentration found in the blood of people with high consumption of low - calorie sweeteners — equal to four cans of diet soda per day — the researchers said they observed increased expression of genes that are markers of fat production and inflammation.

They found similar changes in gene expression in the same genes with increased activity of glucose transporters in both the stem cells and the fat cells, Sen noted.

The tool then uses information from similar cells to make an educated guess about what the level of gene expression should be.

Global gene expression studies found that the LPA - treated mice shared many similar molecular markers as those found in humans with schizophrenia.

SIX3 and a related gene, SIX2, with a similar pattern of expression in human beta cells, encode proteins known as transcription factors that control the expression of many other genes in the cell.

Further studies discovered that the BRAF protein could turn on many itch genes, and they showed similar changes of gene expression in mice with chronic itch induced by dry skin and in mice with allergic contact dermatitis, two of the skin conditions that frequently cause people to scratch incessantly.

In vitro experiments and high - throughput RNA sequencing revealed that CTCF deletion profoundly altered the B lymphocyte transcriptional program, shifting cells from a gene expression profile typical of the germinal center to one more similar to that seen in plasma cells.

The team used gene expression profiling and found that canine B - cell lymphoma expression profiles were similar in many ways to human B - cell lymphoma, thus paving the way for future studies, including therapeutic clinical trials in dogs and humans.

Surprisingly, they found that although the patterns of gene expression — as shown by the RNA sequencing — differed between the hepatocellular carcinomas and the liver cancers with biliary phenotype and depended on the histological type, the overall pattern of mutations in the cells was actually similar between the tumors — of either type — that had emerged in patients who had had infections with either hepatitis C or B, and were different in patients without such infections.

At the same time, there was a similar increase in the expression of the major genes that mediate insulin signaling.

The gene expression patterns were so similar, in fact, that investigators were able to use them to match up the stages in worm and fly development.

Rather than listing specific genes that manifest themselves differently, or are differentially expressed, between queens and workers, the team looked for genes with similar expression patterns across samples that may be involved in maintaining the structural, behavioural and functional differences observed between queens and workers.

However, although fetal tissues from the mother mouse's grandchildren also had similar changes in gene expression, surprisingly, the DNA in these tissues did not carry these methylation differences.

The team found deep conservation of certain processes that likely reflects similar underlying regulatory processes between mouse and man, but there were also significant differences in gene expression during kidney development, as well as in the timing, scale, organization, and molecular profile of key cell types and cell structures.

Differences in gene expression may thus explain how largely similar genomes create such different organisms.

The pattern of gene expression is strikingly similar to that for individual olfactory receptor genes, Liberles says.

Humans have an ortholog of the murine Nrk gene, and considering that the gene expression pattern in breast tumor in Nrk mutant mice was similar to that in human luminal B breast cancer, the findings of this study may lead to further understanding of the mechanisms of human breast cancer suppression and to advances in its diagnosis and therapy.

Separate analyses in which relative expression values were normalized with the relative expression values of each control gene yielded similar results.

Examining the muscles of insulin - resistant mice, the scientists found similar boost in the expression of those key genes.

While S. pistillata's galaxin - like gene was up - regulated during the daytime treatment, the galaxin gene was down - regulated, and was similar to night - time expression levels.

A further 25 days in medium containing FGF2 and Noggin mediated the derivation and expansion of RPCs which had a similar global gene expression pattern to cells of the embryonic day 14 (E14) mouse retina.

A detailed comparison of gene expression signatures between ETP ALL tumors and and normal human hematopoietic progenitor cells revealed a somewhat surprising finding: ETP - ALL expression patterns were less consistent with early T - cell precursors, as might have been expected, but more similar to the expression profile of normal hematopoietic stem cells and granulocyte macrophage precursors.

Although the gene sequences from human and chimpanzee remain very similar, previous studies in tissues other than the brain have shown that gene expression varies widely.

«What we found is that the majority of the gene expression patterns are very similar in human and mouse,» Yue said.

Reducing expression of a gene called PTHR1 causes an blockage of the aorta similar to human aortic coarctation (lower panel).

Another set of tissues show a more sustained response, with gene expression changes of similar magnitude occurring through all PMI intervals (Fig. 2c).

The bags» locations in the genome are similar across cell types, although the bags» contents and roles can change from transcription factors (blue OSN oval) and enhancers (red box) that promote the gene (green) expression (left diagram) or to repressors (right diagram) that inhbit gene expression (gray box).

These featured similar anorexigenic effects of intranasal insulin with decrease in meal frequency and total food intake together with comparable changes in hypothalamic gene expression (262, 264).

To compute the correlation values of gene expression and PMI without the covariates, a procedure similar to the above was used where Pearson correlation is obtained between gene expression and PMI values (Supplementary Fig. 38).

Click «Expression Details» to view all expression annotations and details for this locus, including a visualization of genes that share a similar expressioExpression Details» to view all expression annotations and details for this locus, including a visualization of genes that share a similar expressioexpression annotations and details for this locus, including a visualization of genes that share a similar expressionexpression pattern.

We also observed that parthenotes from in vitro matured oocytes have similar mRNA expression levels of the majority of studied genes compared to IVF / ICSI embryos at the blastocyst stage.

This architecture of language is conceptually similar to the molecular language that regulates gene expression, Panne says.

We further extended our analysis of pluripotency gene expression to a much larger scale to potentially identify similar signaling cascades that might be conserved between hNSCs and hESCs.

This is just the first of a series of similar studies, said Gilad, that will look at changes in gene expression over evolutionary time.

Both mouse and human iPSCs are similar to embryonic stem cells (ESCs) with respect to their morphology, cell behavior, gene expression, epigenetic status and differentiation potential both in culture and in vivo.

Only small sets of genes are unusually variable among replicates (Figure 1A — B) and the distribution of gene expression is very similar between males and females (density plots in Figure 1C).

[53] We have also demonstrated similar effects of GHRH antagonists on in vivo cytokine gene expression by HCC1806 and MX - 1 triple negative human breast cancer.

Moreover, in PrEn precursors, the Nanog low population can itself be split based on the expression of Oct4 or SSEA - 1 into a state expressing reasonably high level of PrEn genes (V+S −), and a less differentiated cell type exhibiting a PrEn bias, but with similar regenerative capacities to the Nanog high population (V+S +).

In agreement with this, both wt STAT2 and mutant STAT2 - Y690F displayed a similar effect on the luciferase reporter gene expression in U3A cells without IFNα.

A statistically significant dependency between gene expression and total exon length has indeed been found in C. elegans, but a similar analysis in humans failed to demonstrate this association [85].

«After feeling comfortable with the accuracy of the statistical model, we can scale up to search among thousands of genes to discover those with similar expression patterns.»

The mouse makes an excellent model for human disease because the organization of their DNA and their gene expression is similar to humans, with ninety - eight percent of human genes having a comparable gene in the mouse.

This method groups genes with similar expression profiles, an indication that they may function in similar pathways.

CT values for cyclophilin were somewhat more variable in cells isolated by flow cytometry and frozen prior to analysis, compared to freshly isolated and unmanipulated cells, but the gradients in patterns of gene expression were similar for cells isolated by the two techniques (Figure 3a — d).