Shea notes that although he and his colleagues have yet to finalize their measurements on how well their nanoparticles bind to various PLA2 molecules, their test - tube results suggest that they could have
a similar high affinity for PLA2s as their previous nanoparticles had for melittin, the bee venom protein that stopped the toxin in animal studies.
Remarkably, both lineages have incurred a three - residue deletion in CDR2 during maturation suggesting the immunogens imposed constraints which resulted in a
similar structural solution to
high affinity binding that was achieved by different underlying sequences.