The work skirts a problem that has cropped up in experimental vaccines made from
a similar human adenovirus — they don't work if you've already been exposed to the natural virus.
Not exact matches
The significant overall sequence divergence of TMAdV from known
human and simian
adenoviruses is highlighted by the finding that PAdV - A (porcine
adenovirus A), a non - primate mammalian
adenovirus, shared only a slightly less
similar whole - genome pairwise identity to TMAdV of 47.0 % (Fig. 4).
The closest
human adenoviral relatives were the species D
adenoviruses, which share 54.3 % to 55.1 % identity to TMAdV, with
human adenoviruses of other species slightly less
similar (51.1 % — 54.6 %).
After removal of
similar viral genomes, bootscan plots of the whole genome and individual genes from a subset representing
human / simian
adenoviruses in species A — G and all non-primate vertebrate
adenoviruses were generated.
Synthesis of
human adenovirus early RNA species is
similar in productive and abortive infections of monkey and
human cells