We observed
similar robust increases of intracellular calcium concentrations in response to KCl and ATP in both GFP - expressing (n = 28) and GFP - nonexpressing cells (n = 12), whereas 5 - HT elicited an increase in intracellular calcium only in GFP - expressing cells (KCl: t (40) = 0.98, p = 0.33; ATP t (38) = 1.04, p = 0.30; 5 - HT: t (38) = 5.24, p < 0.0001 Student's t tests; Fig. 4A, B, F).
Not exact matches
«This research provides really
robust evidence that mercury exposure from fish consumption at levels commonly seen in [the] U.S. and
similar countries is not linked to an
increased risk of cardiovascular disease,» says Dariush Mozaffarian, MD, the lead author of the study and an associate professor of cardiovascular medicine at Brigham and Women's Hospital and Harvard Medical School, in Boston.
The
increase in intracellular NAD elicited by CD38 deletion significantly activated SIRT1 and prompted clinical phenotypes
similar to those expected for SIRT1 activation, including protection against diet - induced obesity and a
robust deacetylation of SIRT1 targets.