Sentences with word «simvastatin»

There was no effect of simvastatin on lung function or general or disease - specific quality of life.

The median number of days to first exacerbation also did not differ significantly: 223 days for simvastatin and 231 days for placebo.

After about five years, 8 percent of patients who took simvastatin (a synthetic version of lovastatin, marketed as Zocor) had died, compared with 12 percent who took a placebo, a 30 percent lower mortality rate.

MRC / BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high - risk individuals: a randomised placebo - controlled trial

Inegy combines the widely - used statin drug simvastatin with a new medication called ezetimibe.

alarmed my doc, blamed it on genetic traits and prescribed me statin Simvastatin on 12/24/10.

The use of lipophilic, or fat - soluble, statins such as simvastatin and atorvastatin was associated with a reduced risk of Parkinson's, while no such association was found for hydrophilic, or water - soluble, statins such as pravastatin and rosuvastatin.

«In conclusion, 40 mg of daily simvastatin added to usual care did not reduce exacerbation rate or prolong time to exacerbation in moderate to severe COPD patients at risk for exacerbation,» the researchers reported.

However, the cholesterol - lowering drug simvastatin increased the ApoA - I levels by 20 percent in these cells.

If you shop around, you might pay $ 5 to $ 10 a month for generic simvastatin (Zocor).

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S).

In the years following, a posse of other cholesterol fighters joined simvastatin to create what would become a $ 20 billion — plus annual market: pravastatin (Pravachol), fluvastatin (Lescol), atorvastatin (Lipitor), cerivastatin (Baycol), rosuvastatin (Crestor) and finally pitavastatin (Livalo).

Participants were prescribed atorvastatin at a daily dose of 10 mg, and only a few people in the non-blinded phase used simvastatin.

«Furthermore simvastatin had no effect on lung function, quality of life, severe adverse effects or mortality.»

They found that people with the gene variant had the highest risk of side effects when they were given a statin called simvastatin, but this risk was much lower when they took pravastatin.

They found that CXCL10 secretion was lower from simvastatin - treated monocytic cells than in control - treated monocytic cells.

(Coincidentally, a new study suggests that Simvastatin actually lowers the risk of Parkinson's and Alzheimer's diseases.)

• Able to reduce the statin dose if LDL - C decreased to < 39 mg / dL (1.0 mmol / L)(per investigator discretion in IDEAL [47]-RRB- or reduce the statin dose if total cholesterol was < 100 mg / dL on 2 successive visits (AFCAPS [17]-RRB- or reduce by 10 mg simvastatin per day if LDL - C was < 40 mg / d (HATS [121]-RRB-, although they continued on study drug no matter how low the cholesterol in CARDS (75).

The HARP study showed that 80 mg of simvastatin administered acutely to patients with acute lung injury showed significant improvements in organ failure scores, suggesting that statins modulate the systemic inflammation after only a short duration of treatment [17].

Although these and other results are promising (in a previous study led by Dr. Becker, a combination of red yeast rice and fish oil outperformed simvastatin, the generic version of Zocor), people with high cholesterol shouldn't race to the vitamin store just yet.

Lipophilic statin drugs such as atorvastatin, simvastatin seem to work best.

A comparative clinical study of hypolipidemic efficacy of Amla (Emblica officinalis) with 3 - hydroxy -3-methylglutaryl-coenzyme-A reductase inhibitor simvastatin.

The severity of exacerbation was not impacted by whether the patient took simvastatin or placebo.

The study was stopped early because an interim analysis conducted by the data safety monitoring board demonstrated futility for simvastatin to provide benefit for COPD.

Analysis of pre-treatment and post-treatment brain MRI scans showed a reduction in the average atrophy rate to 0.3 % a year with simvastatin, a 43 % reduction (when adjusted for factors such as age and gender) compared with placebo.

The researchers also devoted extra attention to the nine most common cardiovascular drugs — such as simvastatin, which is prescribed 96.8 million times a year.

of daily simvastatin (statin drug) added to usual care did not reduce exacerbation rate or prolong the time to exacerbation in patients with moderate to severe COPD.

Indeed, the researchers found that simvastatin increased the drug sensitivity of MDA - MB - 231 cells and inhibited the cells» ability to metastasize when injected into mice.

I started on Simvastatin in 2004.....

For example, ninety 10 - mg tablets of generic simvastatin, a drug used to lower cholesterol, sell for around $ 90, while the same amount of Zocor, the brand - name version, costs about $ 400.

Moringa also has cholesterol - lowering properties, and one animal study found its effects were comparable to those of the cholesterol - lowering drug simvastatin.11 As noted in the Journal of Ethnopharmacology: 12

The study examined the proliferative capacity of human satellite cells when exposed to the statin simvastatin.

Findings from the MS - STAT trial showed that a high, daily dose of simvastatin was safe, well tolerated, and slowed brain atrophy (shrinkage) by 43 % over two years compared with placebo.

«This is the first randomized, controlled trial to examine the question of whether the class of drugs called statins (simvastatin) may be useful in preventing COPD exacerbations,» said Dr. Criner, Director of Temple's Lung Center and Professor of Medicine at Temple University School of Medicine.

COPD exacerbation rates were similar in the two groups: 1.36 per year among those taking simvastatin and 1.39 per year for the placebo group.

daily of simvastatin, a common statin drug used to prevent heart attack and stroke, and 447 took a daily placebo, or dummy pill.

To investigate the potential of simvastatin in the progressive stage of MS, the MS - STAT trial randomly assigned 140 people with secondary progressive MS (aged 18 - 65 years) to receive either 80 mg of simvastatin or placebo for 2 years.

Researchers compared the inflammatory response of control - treated versus simvastatin - treated cells to RV by measuring CXCL10 secretion, an implicated therapeutic target for virus - induced asthma exacerbations.

Simvastatin was generally well tolerated and serious adverse events were similar between the two groups (20 % placebo vs 13 % simvastatin).

To make their discovery, the researchers isolated human blood monocytes and lung macrophages from patients with allergies and / or asthma and treated the cells with simvastatin, a commonly prescribed statin drug.

Results of a phase 2 study published in The Lancet suggest that simvastatin, a cheap cholesterol lowering drug, might be a potential treatment option for the secondary progressive, or chronic, stage of multiple sclerosis (MS), which is currently untreatable.

About three - quarters of the statin prescriptions in Mansi's data were for simvastatin, sold as Zocor.

Results: Simvastatin, but not pravastatin, reduced CSF levels... of phospho - tau - 181 (p - tau181) in all subjects.

Methods: We measured levels of cerebrospinal fluid (CSF) AD biomarkers following 14 weeks of treatment with simvastatin (a CNS permeant statin; n = 10) at 40 mg / day or pravastatin (a CNS impermeant statin; n = 13) at 80 mg / day in hypercholesterolemic subjects without dementia.

Results: Simvastatin, but not pravastatin, reduced CSF levels

On the roster: hydrochlorothiazide, atorvastatin, amlodipine, simvastatin and others.

A physician considering prescribing simvastatin for high cholesterol, for example, might consult the system and find out the patient has a genotype with an increased risk for developing simvastatin - induced myopathy.