Sentences with phrase «single amino acid change»

Brunger and his colleagues found that altering the toxin at the binding site by single amino acid changes (obtained from the high resolution crystal structure) drastically reduced its toxicity.

They also found that such single amino acid changes occurred at only seven places on its surface — all located near the receptor binding site (the area where the flu virus binds to and infects host cells).

Using a combination of laboratory assays and computer algorithms, the team tested various mutations in HB36.5, looking for single amino acid changes that would increase how tightly the protein bound to a diverse group of hemagglutinins.

By March 2014 — about the time the epidemic was detected, but some 3 months after the first case actually occurred — the sequences had split into two distinct lineages, one of which was characterized by a single amino acid change in a region of the virus's surface protein and allows it to bind to cells.

Additionally, they found these single amino acid changes occur at only seven places on its surface — not the 130 places previously believed.

For instance, the researchers have pinpointed a single amino acid change that seems to be critical in highlighting how the protein assembles itself from simpler building blocks.

A single amino acid change in one of the virus's glycoproteins, for example, allowed the virus to replicate about 40 times easier in the bug than it once did.

They characterized the set of HA mutations required to increase the preference of the viruses for human receptors, discovering that only a single amino acid change in the HA sequence is necessary for this to occur.

Now, a team led by Michael Egan, Bai Lu, and Michael Weinberger, at the National Institutes of Health (NIH) in Bethesda, Maryland, has found that a single amino acid change in BDNF — a swap of methionine for valine at position 66 — can affect a person's ability to perform a memory task.

A single amino acid change (red dot) in this large protein may make people more susceptible

We generated an Xpd knock - in allele with a point mutation encoding a single amino acid change (XPDG602D) found in the XPCS patient XPCS2 (Figure 1A — 1C).

It is difficult to distinguish the effects of a single amino acid change caused by those changes in our DNA.»

In hAgo1, Joshua - Tor and her team, which also included CSHL Professor and HHMI Investigator Greg Hannon, found a single amino acid change in this key sequence.

Using this method, Bjorkman and her colleagues have designed a new antibody that introduces a single amino acid change to a natural HIV antibody.

A single amino acid change in turnip crinkle virus movement protein p8 affects RNA binding and virulence on Arabidopsis thaliana

«We found that mouse polyomaviruses with a single amino acid change in their shell elicit a very different magnitude and quality of the T cell response that is needed to control the infection,» Lukacher said.