Sentences with phrase «single cell analyses»

The far more nuanced and precise data produced by single cell analyses will allow for better understanding of pancreatic islet function and dysfunction at the cellular level.

The new facilities will render technological advances in Sweden and abroad widely available to the Swedish scientific community, with the goal for the region to become world leading in advanced molecular single cell analyses.

The theme for today's SciLifeLab Science Summit was single cell analyses, from microbes to human brain.

2 May 2012 Annual Hitachi Lectureship at AAAS Focus: From DNA Sequencer to Single Cell Analysis: Development of Innovative Technologies and Instruments Featuring: Hideki Kambara, Fellow, Hitachi, Ltd..

«Our circulating tumor cell device can release a tumor cell captured from a blood sample, enabling single cell analysis,» says Liu.

This way, single cell analysis could lead to a better understanding of human health, diagnosing and monitoring, and the development of personalized treatments.

-- Combining the detailed information from existing single cell analysis with our in situ sequencing method can be powerful and find great use in both research and diagnostics, says Mats Nilsson.

We are using live cell imaging, single cell analysis and gene editing to resolve the molecular determinants of human epidermal progenitor cell division outcomes (two progenitors, two differentiating cells or one or each) and the mode of cell division (maintenance mode vs repair mode).

We focus on squamous tissues, the skin epidermis and the lining of the oesophagus, using transgenic models, novel sequencing approaches, live imaging and single cell analysis to uncover key steps in cancer development, with aim of developing rational interventions to decrease cancer risk.

By combining advanced approaches such as cell sorting and single cell analysis, researchers will gain a better understanding of the complex genetic landscape of disease.

The Swedish Biodiversity Program aims to target biodiversity of bacteria, viruses, archaea and eukaryotes and combinations thereof to promote large research projects aiming to uncover and understand genomic variability in nature by use of massively parallel sequencing and microbial single cell analysis.

Single cell analysis identifies new immune cell precursor; reveals surprising heterogeneity in a poorly understood subgroup of antiviral T lymphocytes

The present study shows that such a gradient is also seen at the level of single cell analysis, but reveals that there is considerable cell - to - cell variation within this gradient in the expression of pluripotency genes.

Drop - Seq, and other methods for single cell analysis, usually begins with a dissociated tissue, but inside the body a cell's location matters a great deal.

In addition to its high throughput capabilities, Drop - Seq addresses two additional single cell analysis challenges — high cost and risk of contamination.

Not exact matches

The advantages of MFCs may allow widespread use of diagnostic procedures that are currently too expensive to implement (e.g., prescreening for cancer) while the new capabilities may dramatically improve our ability to understand complex diseases such as cancer (e.g., through single - cell analysis).

The NB activity in Alberta is far ranging, with such research as self - assembled nanostructures (M. J. Brett), single - cell cancer analysis (L. M. Pilarski), computational modeling (D. Wishart), micro-total analysis systems or lab on a chip (D. J. Harrison), cell identification and manipulation (K. Kaler), and microsystems and medical diagnostics (Backhouse).

The study, «Spectrophotometric analysis at the single - cell level: elucidating dispersity within melanic immortalized cell populations,» was supported in part by the Mizzou Advantage program, an initiative that fosters interdisciplinary collaboration among faculty, staff, students and external partners to solve real - world problems in four areas of strength identified at the University of Missouri, including Food for the Future, One Health / One Medicine, Sustainable Energy and Media of the Future.

«That's what single - cell analysis lets you do.

These improvements push the boundaries of nucleic - acid detection and fragment sizing, affecting applications such as single - cell nucleic acid analysis, PCR - free preparation of NGS library preparation, bacterial artificial chromosome clone sizing, and exosome analysis.

The result is a comprehensive workflow for robust, flexible, and high - throughput single - cell analysis.

Researchers who plan to do a lot of single - cell RNA analysis can even buy complete systems for it right off the shelf.

10x's software includes not only the basic functions required to deconvolute the single - cell data, but also a suite of tools for analysis and visualization.

The new platform processes hundreds to tens of thousands of cells per day, providing scalable, sensitive, single - cell sequencing with simple yet powerful data analysis.

Researchers are already using single - cell analysis to identify genetic variations within tumors and tissues, and Langsdorff says the technique is quickly establishing a foothold in microbiology as well.

The tool acts with surgical precision to replace only abundances that have most likely dropped out and can be used in any type of single - cell gene - expression analysis.

The authors used a time - lapse video recording coupled to single - cell molecular analyses to study the process step - by - step and found that fate decision is not a unique programmed event, but the result of a very dynamic process composed of spontaneous fluctuation and selective stabilisation of alternative cellular states.

These technologies offer a powerful set of tools for biological analysis at the molecular and single - cell level in the life sciences, pharmaceutical, and clinical laboratory industries.

The ICELL8 Single - Cell System can isolate thousands of single cells and process specific cells for analysis, includinSingle - Cell System can isolate thousands of single cells and process specific cells for analysis, includinsingle cells and process specific cells for analysis, including NGS.

Labs have started tackling the problem with a tool called single - cell transcriptome analysis, which gives readouts of all the genes that are active in individual cells.

Co-first author Alice Eunjung Lee, PhD, from the lab of Peter Park, PhD, at the Center for Biomedical Informatics at Harvard Medical School, developed the study's retrotransposon analysis tool, which detects somatic retrotransposon mutations in single - cell sequencing data.

«Democratizing single - cell analysis.»

With current techniques it is not easy to make comparative analysis of influenza viruses with single mutations in their genomes, and it is extremely difficult to identify factors that limit the reassortment process between two influenza genomes that have infected the same cell.

Genetic analysis places Loki squarely within the single - celled archaea.

The profile of CD4 - TEMRA was highly heterogeneous across donors, with four distinct clusters identified by the single - cell analysis.

Single - cell differential gene expression analysis revealed a spectrum of known transcripts, including several linked to cytotoxic and costimulatory function that are expressed at higher levels in the TEMRA (effector memory T cells expressing CD45RA) subset, which is highly enriched for CD4 - CTLs, compared with CD4 + T cells in the central memory (TCM) and effector memory (TEM) subsets.

Simultaneous T cell antigen receptor (TCR) analysis in single cells and bulk subsets revealed that CD4 - TEMRA cells show marked clonal expansion compared with TCM and TEM cells and that most of CD4 - TEMRA were dengue virus (DENV)-- specific in donors with previous DENV infection.

Using the Single - Cell Automatic Analysis and Isolation System developed in 2013, this group isolated single OSNs responding to specific odorants in a time - lapse single - cell - array cytometric manner and identified the OR gene through single cell polymerase chain reaction Single - Cell Automatic Analysis and Isolation System developed in 2013, this group isolated single OSNs responding to specific odorants in a time - lapse single - cell - array cytometric manner and identified the OR gene through single cell polymerase chain reaction (PCell Automatic Analysis and Isolation System developed in 2013, this group isolated single OSNs responding to specific odorants in a time - lapse single - cell - array cytometric manner and identified the OR gene through single cell polymerase chain reaction single OSNs responding to specific odorants in a time - lapse single - cell - array cytometric manner and identified the OR gene through single cell polymerase chain reaction single - cell - array cytometric manner and identified the OR gene through single cell polymerase chain reaction (Pcell - array cytometric manner and identified the OR gene through single cell polymerase chain reaction single cell polymerase chain reaction (Pcell polymerase chain reaction (PCR).

He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.

The first stage of the trial, which involved an analysis of circulating tumor cells from a single blood draw of several dozen patients, has demonstrated strong potential.

Adds Liu: «With metastatic cancers accounting for around 90 % of deaths from solid tumors, the hope is that one day a device that can enable the analysis of single tumor cells circulating in the blood could make a big difference in early diagnosis, detection and monitoring of numerous types of cancer, without invasive biopsies.»

«Such single - cell analyses are very important, because measurements of entire cell communities are often misleading since all the heterogeneity of the the single cells has been averaged out.»

Our side by side analysis uncovers the dynamics of epigenetic programming occurring in germ cell development at single base resolution in human and mouse cells.»

One area of current research is single cell manipulation and analysis using droplet microfluidics.

«Nature, meet nurture: Single - cell analysis reveals diverse landscape of genetic changes in the brain after a sensory experience.»

HM - SNS allows researchers to sequence the genomes of single tumor cells and study multiple cells simultaneously, both lowering the cost and boosting data analysis for such studies.

«Single - cell analysis of embryos reveals mis - segregation of parental genomes.»

New genetic analyses of tropical marine microorganisms have revealed that some species of single - celled plankton are converting significant amounts of nitrogen from the air into nutrients, helping to fortify the base of the ocean's food pyramid.

«We think single - cell analysis could potentially augment traditional biopsy - core histopathology, significantly improving risk assessment and informing treatment decisions, especially in borderline cases.»

Using single cell RNA sequencing analysis, the Cairns lab profiled cells individually, establishing the gene expression profile in human sperm stem cells.