Sentences with phrase «single cell studies»

Development of methodology to facilitate single cell studies of structural variation, and integrating state - of - the - art microscopy methods with single cell sequencing.

A single cell study of marine microeukaryotic biodiversity.

Not exact matches

Co-authored by David Catling, an atmospheric chemist at the University of Washington in Seattle, the study peers deep into our planet's history to devise a novel recipe for finding single - celled life on faraway worlds in the not - too - distant future.

«In theory, conventional single - junction solar cells can only achieve an efficiency level of about 34 percent, but in practice they don't achieve that,» said study co-author Paul Braun, a professor of materials science at Illinois.

Our studies involve the use of a whole - cell patch clamp, an electrophysiological approach to measure the transmembrane current of a single cell, to identify the effects of herbs on the cardiovascular system.

Eric Betzig, Stefan W. Hell and William E. Moerner share the 2014 chemistry Nobel for the development of super-resolved fluorescence microscopy, which has enabled the study of single molecules in ongoing chemical reactions in living cells.

The study, «Spectrophotometric analysis at the single - cell level: elucidating dispersity within melanic immortalized cell populations,» was supported in part by the Mizzou Advantage program, an initiative that fosters interdisciplinary collaboration among faculty, staff, students and external partners to solve real - world problems in four areas of strength identified at the University of Missouri, including Food for the Future, One Health / One Medicine, Sustainable Energy and Media of the Future.

To understand how a single cell knows when, where, and how to divide, Skop studies the embryos of Caenorhabditis elegans, the roundworm.

Through a variety of «high tech» approaches, including the isolation of monoclonal antibodies from single B cells and ultra-deep sequencing of shifting viral populations over more than three years of infection, the researchers studied one woman who developed potent broadly neutralizing antibodies.

A study analyzing brain tumor genomics on a single - cell level has found evidence that cancer stem cells fuel the growth of oligodendrogliomas, a slow - growing but incurable form of brain cancer.

To more accurately reflect the mechanisms driving oligodendrogliomas, the researchers used RNA sequencing to study directly, on a single - cell level, gene expression in samples from six early - stage human tumors.

As costs come down and methods become more standardized, experts in the field expect single - cell sequencing to become the new model for both transcriptomic and genomic studies.

«What we want this technology to achieve is confidence to switch to single embryo transfers instead of the practice of transferring multiple embryos without [an accompanying] reduction in pregnancy rate,» study co-authors Gayle Jones and David Cram, senior research scientists in immunology and stem cells at Monash University in Australia, wrote in an e-mail.

A single genetic mutation made the Zika virus far more dangerous by enhancing its ability to kill nerve cells in developing brains, a new study suggests.

The results of the study were obtained by infecting laboratory - grown cells with forms of the CMV virus which differed only by the removal of a single gene.

But three studies from the past year may present a road map for singling out the cancer cells alone.

Circulating tumor cell (CTC) clusters — clumps of from 2 to 50 tumor cells that break off a primary tumor and are carried through the bloodstream — appear to be much more likely to cause metastasis than are single CTCs, according to a study from investigators at the Massachusetts General Hospital (MGH) Cancer Center.

The authors used a time - lapse video recording coupled to single - cell molecular analyses to study the process step - by - step and found that fate decision is not a unique programmed event, but the result of a very dynamic process composed of spontaneous fluctuation and selective stabilisation of alternative cellular states.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study published June 18th in the journal Cell.

In a study led by the University of Montana and co-authored by Purdue mycologist M. Catherine Aime, researchers show that lichens across six continents also contain basidiomycete yeasts, single - celled fungi that likely produce chemicals that help lichens ward off predators and repel microbes.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

Delivering a single injection of a scar - busting gene therapy to the spinal cord of rats following injury promotes the survival of nerve cells and improves hind limb function within weeks, according to a study published April 2 in The Journal of Neuroscience.

In a recent study published in Angewandte Chemie International Edition, Associate Professor of Chemistry Wei Min's team developed a new glucose analogue that can mimic the natural glucose, and imaged its uptake as energy source by living cancer cells, neurons and tissues at the single cell level.

The oldest form of life studied for auxin were single - cell, green algae, dating back to the deep past of a billion years ago.

Co-first author Alice Eunjung Lee, PhD, from the lab of Peter Park, PhD, at the Center for Biomedical Informatics at Harvard Medical School, developed the study's retrotransposon analysis tool, which detects somatic retrotransposon mutations in single - cell sequencing data.

By now, European astronauts had hoped to be established in their space laboratory called Columbus, where they would be melting and solidifying conductive metals, studying microgravity effects on single - celled organisms, investigating human balance disorders, and carrying out dozens of other experiments.

A combination approach In a study published yesterday in the journal Applied Physics Letters, the researchers presented a device that combines the two materials but functions as a single, monolithic cell.

Using single cell transcriptogenomics to probe the cell's defense mechanisms, study published in Mutation Research — Fundamental and Molecular Mechanisms of Mutagenesis

Just as no two people possess the same genetic makeup, a recent study has shown that no two single tumor cells in breast cancer patients have an identical genome.

Published in Nature Communications, the approach could open the door for detailed single - molecule localization studies in many areas of cell research.

The research group studies viruses that infect microbes, and specifically bacteria and archaea, single - cell microorganisms similar to bacteria in size, but with a different evolutionary history.

Navin's team developed Nuc - Sec as a single - cell genome sequencing method and applied it to study how cell mutations occur in both types of breast cancer.

They then grew these into organoids — 3D «mini-guts» — in the laboratory to amplify the single cells so they could be studied.

Prof Hans Clevers, from Hubrecht Institute in the Netherlands, joint corresponding author on the paper, said: «Organoids had not been used to study single cancer cells before.

Next, the team used other mouse models in which part of the lung was removed and single cell culture to study the plasticity of cell types during lung regrowth.

This enabled us to study each cell without the errors that standard single cell methods bring.

«We are currently developing tools in the lab to study the cell cycle and cellular morphology of Sulfolobus at the single - cell level under the microscope.

The study was performed using single stem cells cultivated to provide sufficient DNA for whole genome sequencing.

The mammalian cerebral cortex, long thought to be a dense single interrelated tangle of neural networks, actually has a «logical» underlying organizational principle, reveals a study appearing Feb. 27 in the journal Cell.

So instead of studying the whole animals, he began isolating single nerve cells from the mole rats and investigating them in lab dishes to track the molecular basis of the rodent's pain insensitivity.

The assay can measure the lag times and growth rates of as many as 80,000 individual microcolonies in a single 24 - hour experiment, opening up a powerful new high - throughput tool to study the complex interplay between cell growth, division and metabolism under environmental conditions that are likely to be ecologically relevant but had previously been difficult to study in the laboratory.

The Lac - Operon has been studied for more than 50 years, and still, we discovered new important properties when looking at it with single cell resolution,» says van Nimwegen.

Single bacterial cells grow in about 2000 channels of a thousandth of a millimeter in diameter and can be individually studied in detail by the researchers in Prof. Erik van Nimwegen's group at the Biozentrum, University of Basel.

In a study published in Science in June, paleoceanographer Bärbel Hönisch and colleagues at Columbia University examined the remnants of planktonic foraminifera — single - celled creatures with elaborate shells — buried beneath the seafloor off the coast of Africa.

A study of the way malaria parasites behave when they live in human red blood cells has revealed that they can rapidly change the proteins on the surface of their host cells during the course of a single infection in order to hide from the immune system.

Because of this we were able to find differences in genome folding on the level of single cells: these cell - to - cell variations were missed in conventional Hi - C due to the averaging over millions of cells,» says Ilya Flyamer, former Vienna Biocenter (VBC) summer student and then Master student and one of the first authors of the study.

The Dicty cells were taken from the single - celled organisms that make up slime molds, whereas the HL60 cells are highly studied human cancer cells.

Through the use of time - lapse microscopy, they were able for the first time in this context to observe and to study sporulation and spore revival at the single - cell level — and how they correlate.

HM - SNS allows researchers to sequence the genomes of single tumor cells and study multiple cells simultaneously, both lowering the cost and boosting data analysis for such studies.

Janetopoulos and his group study Dictyostelium discoideum cells, which are technically single - cell organisms, but have the remarkable ability to join together into a single organism when times are tough, and migrate to a location where food is more plentiful.