Sentences with phrase «single celled model»

In a new study, published in Current Biology this week, a research team from Uppsala University reports new insights into the regenerative capabilities of Stentor, a single celled model organism for regeneration biology.

Apart from these single cell models, Dijkstra also developed models including connections.

Not exact matches

The discovery, reported in June in Cell, completely breaks with the standard model of facial recognition, which claims each face you recognize is represented by a single neuron (one cell firing when you see your grandmother, another when you see Jennifer AnistCell, completely breaks with the standard model of facial recognition, which claims each face you recognize is represented by a single neuron (one cell firing when you see your grandmother, another when you see Jennifer Anistcell firing when you see your grandmother, another when you see Jennifer Aniston).

Freedom Scientific's larger Focus displays include 40 - and 80 - cell single - row models, which cost about $ 3,900 and $ 7,800, respectively.

The NB activity in Alberta is far ranging, with such research as self - assembled nanostructures (M. J. Brett), single - cell cancer analysis (L. M. Pilarski), computational modeling (D. Wishart), micro-total analysis systems or lab on a chip (D. J. Harrison), cell identification and manipulation (K. Kaler), and microsystems and medical diagnostics (Backhouse).

«Transplanted hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»

As costs come down and methods become more standardized, experts in the field expect single - cell sequencing to become the new model for both transcriptomic and genomic studies.

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.

The scientists, in collaboration with IBM, are launching the effort by building a computer model of the neocortical column of a rat, a single circuit of about 10,000 cells, each of which is capable of thousands of connections.

«We now have a model that incorporates this seemingly contradictory data and points to a single and simple process for condensed chromosome organization across all cell types.

«Josh wanted someone to come in and build a model of single AII cells to try and understand how the AII works as an input / output device,» Cembrowski explains.

With collaborators from India, Japan, and the United States, the inStem lab is exploring «biochemistry, biophysics, humanized mouse models, and single - cell models.»

He cautions there is a huge gap between the simple response of single - celled animals and the cognitive abilities of developed species, but adds there is no doubt that a combined set of simple circuit models will have more complex behaviour.

Tubo et al. used a single - cell adoptive transfer model in mice to answer this question.

Tissue engineers have been unable to grow epidermis with the functional barrier needed for drug testing, and have been further limited in producing an in vitro (lab) model for large - scale drug screening by the number of cells that can be grown from a single skin biopsy sample.

The bio-bots are modeled after single - celled creatures with long tails called flagella — for example, sperm.

«To our knowledge, our model is the first in which expression of a single gene in postnatal hair cells results in hair cell survival and hearing preservation in mice that otherwise suffer from age - related and noise - induced hearing loss,» Dr. Chen said.

In the plant - model Arabidopsis thaliana, the state of dormancy is maintained by the endosperm, a single cell layer within the seed coat surrounding the embryo, which synthesizes and continuously releases ABA towards the embryo.

Their series of experiments showed that a single application of concentrated, mature B cells accelerated wound healing and improved the quality of tissue repair in both animal models.

Next, the team used other mouse models in which part of the lung was removed and single cell culture to study the plasticity of cell types during lung regrowth.

The team modelled how the membrane changed, enabling LUCA's descendants to move to new, more challenging environments and evolve into two distinct types of single - celled organism, bacteria and archaea, creating the deepest branch of the tree of life.

«Even though we only demonstrated the technique with model membranes and single cells, this technique is translatable to biological tissue,» said Brasselet.

The study used whole - exome sequencing to characterize genetic alterations that occur at the single nucleotide level for all genes in 25 cell lines commonly used as models of bladder cancer.

Dijkstra looked into this mechanism in detail, using mathematical models describing the biophysics of a single cell.

This visual abstract depicts how Wei et al. utilize single - cell phosphoproteomic analysis of patient derived glioblastoma models to identify shifts in signaling coordination following short - term treatment with kinase inhibitors, which facilitates the design of combination therapy approaches with reduced resistance and improved efficacy.

Engram cell in AD mouse — This image depicts a single memory engram cell (green) in the hippocampal dentate gyrus (DG) region of a mouse model of early Alzheimer's disease.

In the humanized mouse model under the conditions studied here, partial loss of cxcr4 in human T cells due to treatment with X4 - ZFNs provided selective pressure for either the evolution or emergence of a pre-existing single amino acid mutation in the V3 loop of the infecting X4 HIV - 1 strain that enabled it to use CCR5 as efficiently as CXCR4.

The scientists used diffusion maps — a basic way to order snapshots of single cells along their developmental journey — but they plan to study developmental trajectories using a new algorithm called Wishbone, which uses single - cell RNA sequencing and mass cytometry data to specifically model branching steps during cell differentiation (Nat Biotechnol, 34:637 - 45, 2016).

3D modeling of chromatin structure: is there a way to integrate and reconcile single cell and population experimental data?

Bethesda, USA (2016 - present) Research areas: Super-resolution microscopy, single - molecule imaging, gene expression, computational modeling and data analysis This section includes all projects during my postdoctoral research stay at the National Institutes of Health in Bethesda, MD (Unites States): (9) Understanding gene expression in eukaryotic cells»

Single - cell technologies will be applied to experimental model systems such as organoids, miniature organs grown in the petri dish from one or more cells.

Further research topics are statistical / computational methods to study complex experimental data (e.g. cellular genealogies) and image analysis procedures (e.g. model - based segmentation algorithms in the context of automatic single cell tracking).

Hematopoiesis, where a single hematopoietic stem cell gives rise to the entire blood system, is an important model for differentiation with great medical importance.

«We found several distinctions between sensitive and resistant models detected at the single - cell level, which testified to single - cell sequencing potential usefulness for understanding how these cancers may develop resistance.»

The goal of this work is to characterize the role of dendrites in learning and memory processes so as to formulate a unifying theory regarding their contribution in memory formation across brain regions and abstraction levels.This will be achieved via the development of computational models that start at the single cell level and expand to the microcircuit and the network level, while varying in their degree of biophysical detail.

Towards this goal, we build abstract mathematical as well as detailed biophysical models of neural cells and circuits across multiple brain regions (hippocampus, amygdala, PFC) and abstraction levels (single neurons, microcircuits, neuronal networks).

We focus on squamous tissues, the skin epidermis and the lining of the oesophagus, using transgenic models, novel sequencing approaches, live imaging and single cell analysis to uncover key steps in cancer development, with aim of developing rational interventions to decrease cancer risk.

These epithelial organoid cultures are genetically and phenotypically extremely stable, allowing transplantation of the cultured offspring of a single stem cell, as well as disease modeling by growing organoids directly from diseased patient tissues (45).

For a systems - level understanding of all crucial protein interactions during cell division, we are combining automated single molecule calibrated imaging and computational data analysis with advanced machine learning and modelling approaches to build an integrated protein atlas of the human dividing cell.

Using the oral microbial community as a model system, we are applying functional genomic approaches including Stable Isotope Probing (SIP), metatrascriptomics and directed single cell genomic approaches to enable us to overcome this limitation.

Based on the architecture of the root, the model considered cells within a single file in these two zones (Fig 1A and B).

Cancer cells in intravital mouse models and in vitro display many «modes» of migration, from single isolated cells with round or elongated phenotypes to loosely - / non-adherent «streams» of cells or collective migration of cell strands and sheets.

In the model of herpes simplex virus (HSV)-1 infection of B6 mice, > 90 % of the responding CD8 + T cells use Vbeta10 or Vbeta8 and are directed against a single glycoprotein B (gB498 - 505) epitope, gB - 8p.

The NIH has for years supported research in which human cells are transplanted into animal models, and it continues to fund human / nonhuman chimera research that lies outside the scope of research singled out in its notice of moratorium.»

In our lab we use a combination of quantitative single cell experiments and computer / in silico models to better understand miRNA regulation.

333/12: 00 Identifying critical cell types in complex traits from purified and single - cell expression using a polygenic model.

By developing computational models that are constrained by experimental evidence (neuroimaging, single - cell recording, anatomical, lesion studies), we can generate hypothesis about how brain networks orchestrate behavior.

By using single - cell transcriptomics and computational analysis using a temporal mixtures of Gaussian processes model, termed GPfates, we reconstructed the developmental trajectories of Th1 and Tfh cells during blood - stage Plasmodium infection in mice.

We here describe f - scLVM (factorial single - cell latent variable model), a method based on factor analysis that uses pathway annotations to guide the inference of interpretable factors underpinning the heterogeneity.

First, demonstration of the possibility of modeling different diseases affecting adult cells using a single platform has answered one of the most pressing questions in the human iPS cell — disease modeling field.