Sentences with phrase «single codon»

On average, changing a single codon reduced the fitness of the bacteria, by 0.01 procent per generation.

Brandis and Hughes changed many different codons and showed that changing even a single codon in the gene for this protein into any one of the alternative «synonymous» codons reduced the «fitness» of Salmonella.

To generate the models, Jackson created two mutated versions of the PrP - coding gene by changing a single codon — one of the three - nucleotide «words» in genes that code for the various amino acids in proteins.

Not exact matches

In these and other inherited diseases, 10 to 15 percent of the single - base pair mutations that cause the disease create a misplaced, premature «stop» codon in the middle of the gene — causing the machinery of the cell to prematurely halt synthesis of the protein, which destroys its ability to function.

A key component in the translation process is the ribosome, which migrates along the single stranded mRNA, reading the codons as it goes.

Out of a total of five positively selected SNPs, four represented nonsense mutations resulting in stop codons, three of these in a single ApiAP2 transcription factor gene, and one in SRPK1.

Because each tRNA is specific for a single amino acid, it must be able to recognize the codon on the mRNA that codes for that particular amino acid.

This led to the eventual identification of a single nucleotide substitution in the second codon of a previously unknown gene that is now known to be the cause of PRCD in at least 18 different breeds [23].