Sentences with phrase «single gene for»

Why you would expect their to be a single gene for something as complex as se.xuality when their isn't a single gene for something as simple as height is beyond me.

With the data provided by the FLI researchers, scientists around the world may now set targeted mutations to investigate the relevance of single genes for aging, in order to better understand regulating mechanisms and, eventually, develop new approaches for therapy or prevention of aging - related diseases.

However, even if it were possible to analyse every child's genetics, no single genes for IQ or educational achievement have yet been identified, says Sarah Norcross of the Progress Educational Trust, a UK charity that promotes debate on genetics and reproduction.

Such models aim to elucidate the contribution of single genes for protection against mutations, genomic instability, ageing and ageing related diseases such as cancer.

Not exact matches

The Canadian Patent Office would have to reverse the Patent licenses it has granted to companies who have received them for what's called single gene loci.

(insert your own, southerners backwoods joke here) So Mendel fails, in my mind, to adequately account for the very narrow gene pool (read single - celled organism) that the theory of evolution begins with.

Blakemore argues that a single gene mutation could in fact have been the cause of this increase - for in fact only one extra cell - division step would cause a doubling of brain size.

Europe came through: Last year, Cory received a European Molecular Biology Organization (EMBO) Installation Grant for his lab in mitochondrial biogenesis, and Gülayşe won a Marie Curie International Reintegration Grant from the European Commission to study how single genes can yield different protein products in neurons.

Jaenisch says that the method that identified the single point mutation in SNCA's enhancer could be used to pinpoint additional pathogenic genes for sporadic PD and sift through the GWAS hits for other diseases, including Alzheimer's disease, cancer, diabetes, and multiple sclerosis.

In SIF - seq, hundreds or thousands of DNA fragments to be tested for enhancer activity are coupled to a reporter gene and targeted into a single, reproducible site in embryonic cell genomes.

Many are known to be caused by mutations in single genes, yet for the vast majority no treatments are available.

In yeast, for example, they've found that increasing the activity of a single gene, called Sir2, can significantly extend life span.

Now a single gene is providing some answers, which should lead to a better understanding of sudden infant death syndrome and sleep apnoea, for example.

The disease results from a single mutation in the gene that codes for one of the protein chains that make up the hemoglobin molecule.

Alpha -1-antitrypsin deficiency (A1ATD) is the most common genetic disease of the liver, and is caused by a single nucleotide change in the gene that codes for alpha -1-antitrypsin (A1AT), an enzyme inhibitor that normally protects bodily tissues.

To generate the models, Jackson created two mutated versions of the PrP - coding gene by changing a single codon — one of the three - nucleotide «words» in genes that code for the various amino acids in proteins.

Because dogs appeared to inherit the disorder through a single mutation, Emmanuel Mignot and his colleagues at Stanford University Medical Center decided to sniff around in canine DNA for the flawed gene.

In the new study, the researchers sequenced the entire genome of mice that had undergone CRISPR gene editing in the team's previous study and looked for all mutations, including those that only altered a single nucleotide.

As a single - unit light source, GFP could serve as a perfect molecular tag for tracking genes and proteins in an organism.

The even greater surprise is the recent discovery that epigenetic signals from the environment can be passed on from one generation to the next, sometimes for several generations, without changing a single gene sequence.

Almost immediately such familial genome sequencing proved its value, uncovering mutations responsible for diseases caused by defects in a single gene.

Working with this hypothesis, the researchers conducted a statistical analysis of the CX3CR1 gene in over 7000 schizophrenia and autism patients and healthy subjects, finding one mutant candidate, a single amino acid switch from alanine to threonine, as a candidate marker for prediction.

His suspicionswas confirmed: the children had an identical defect — a missing single nucleic acid, called guanine — in the gene coding for leptin.

The research team used single - gene amplification to study the gene responsible for HIV's major surface protein, env.

Using a technique known as single - cell RNA sequencing, the team explored more than 65,000 individual cells that exist under normal or inflammatory conditions, looking for genes that were more active in one state or subpopulation versus another.

The samples were analyzed by liquid chromatography - mass spectrometry (LC - MS) to characterize the metabolite composition («metabolomics»), and biocrust DNA was extracted for shotgun sequencing to measure single copy gene markers for the dominant microbe species («metagenomics»).

Researchers know that cells chop single genes into shorter pieces called exons, which they mix and match into one transcript for creating a protein.

«This work demonstrates the feasibility of using a single gene editing platform, plus the regenerative power of stem cells to correct genetic mutations and restore dystrophin production for 60 percent of Duchenne patients,» said Pyle, associate professor of microbiology, immunology and molecular genetics and member of the Broad Stem Cell Research Center.

After just a single dose, rat intestinal cells pumped out bacterial lactase for up to 6 months — showing that the gut cells had inserted the gene into their DNA and were using it to manufacture the enzyme.

In 1993, Brunner discovered a predisposition to violence in a single Dutch family carrying a mutation in the gene which makes monoamine oxidase A (MAOA), another enzyme vital for regulating neurotransmitter levels in the brain.

The findings provide proof of principle that restoring the function of a single tumor suppressor gene can cause tumor regression and suggest future avenues for developing effective cancer treatments.

These multigene interactions are subtler and knottier than the single gene drivers of diseases such as hemophilia and cystic fibrosis; spotting them calls for statistical inspiration and rigorous experiments repeated again and again to guard against introducing unproven gene tests into the clinic.

Molecular geneticists dream of having a similarly comprehensive view of networks that control genes: For example, they would like to identify rules explaining how a single DNA sequence can express different proteins, or varying amounts of protein, in different circumstances (see p. 80).

And for about 80 per cent of genes, there is an exact, single match in humans.

It is typically less expensive to get preselected information about the 20,000 or so genes that make up a person's exome — the section of the genome that provides instructions for making proteins — than to perform a more precision - oriented test that targets a single gene.

Sickle cell disease is a recessive genetic disorder caused by a single mutation in both copies of a gene coding for beta - globin, a protein that forms part of the oxygen - carrying molecule hemoglobin.

Yet for years biologists could not find a single gene involved in language.

If youdisable the gene for a single vomeronasal protein in mice, a male mouseloses his ability to distinguish other males from females and will tryto mate with both.

Rare, deadly, and caused by a single gene mutation, it was a perfect proof - of - principle condition for anyone seeking to replace damaged DNA with genes that did the job.

«Single gene encourages growth of intestinal stem cells, supporting «niche» cells, and cancer: Finding in mice could lead to new therapies for damaged organs, cancer.»

Huntingtin, the single gene mutation responsible for the disease, was identified in 1993.

There is little dispute that genetics accounts for a large amount of the variation in people's intelligence, but studies have consistently failed to find any single genes that have a substantial impact.

«What is so remarkable about dati is that females that are mutant for just this single gene can never decide to accept males, no matter how hard the males try to impress them» says Joseph Schinaman, a PhD student and first author of the publication.

Now researchers have identified a single gene, called fruitless (fru), as responsible for the development of male sexual behavior in the fly.

NIPD for single gene disorders in a fetus is diagnostic, as it targets specific genetic changes present in a high risk family.

By studying Arabidopsis plants for which the genes for these transcription factors had been selectively knocked out, the group identified a single transcription factor that when inactive resulted in longer roots.

«This experiment confirmed that this single gene was responsible for all these changes,» Dubcovsky notes.

For Helicobacter pylori, a pathogenic bacterium that colonizes over 40 percent of the world population and is associated with gastric cancer, the team discovered that epigenetic heterogeneity can quickly emerge as a single cell divides, and different subpopulations with distinct methylation patterns have distinct gene expressions patterns.

«By sequencing all of the DNA that codes for mRNA and ultimately, proteins, Dr. Amin and colleagues found a single gene that may account for as much as 4 % of the heritable risk for depression,» said Doctor John Krystal, Editor of Biological Psychiatry.

«For the first time, we can predict the outcomes of modifying multiple genes involved in lignin biosynthesis, rather than working with a single gene at a time through trial and error, which is a tedious and time - consuming process,» says Jack Wang, assistant professor in NC State's College of Natural Resources and lead author of a paper about the research in Nature Communications.