Sentences with phrase «single gene in mice»

Knocking out a single gene in mice can produce symptoms of obsessive - compulsive disorder (OCD), researchers report in tomorrow's issue of Nature.

The loss of a single gene in mice can affect social behavior and impair their brains» ability to filter out distractions — both characteristics of several neurological diseases in humans.

Not exact matches

But, as journalist Steve Connor reports, the reference to editing was intentional: «Scientists have used the genome - editing technology to cure adult laboratory mice of an inherited liver disease by correcting a single «letter» of the genetic alphabet which had been mutated in a vital gene involved in liver metabolism.»

This suggested that obesity in both obese and db mouse strains resulted from a mutation in a single gene in each case.

With a single local injection of the USH1G gene just after birth, the scientists observed a restoration of the structure and mechanosensory function of the inner ear hair bundles — profoundly damaged before birth -, resulting in a long - term partial recovery of hearing, and complete recovery of vestibular function in these mice.

The paper was a landmark, demonstrating «that a single gene mutation in the mouse could extend life span,» says gerontologist Richard Miller of the University of Michigan Geriatrics Center in Ann Arbor.

In the new study, the researchers sequenced the entire genome of mice that had undergone CRISPR gene editing in the team's previous study and looked for all mutations, including those that only altered a single nucleotidIn the new study, the researchers sequenced the entire genome of mice that had undergone CRISPR gene editing in the team's previous study and looked for all mutations, including those that only altered a single nucleotidin the team's previous study and looked for all mutations, including those that only altered a single nucleotide.

The ability to edit a single, carefully targeted gene in each organism means that individual members don't need to be the perfect genetic clones currently filling mouse and fly labs.

To avoid that muddle, Steve Brown and Xue - Zhong Liu, molecular biologists at the Medical Research Council's Mouse Genome Center in Harwell, England, sought families in remote areas of the world, where the families» deafness is more likely to be caused by a single mutated gene.

Other researchers had linked the ank mutation to mouse chromosome 15; in this week's Science, Kingsley's team reports that it's a single typo in a previously unknown gene, which they called ank, that led to a protein about 10 % shorter than the normal version.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

If youdisable the gene for a single vomeronasal protein in mice, a male mouseloses his ability to distinguish other males from females and will tryto mate with both.

«Single gene encourages growth of intestinal stem cells, supporting «niche» cells, and cancer: Finding in mice could lead to new therapies for damaged organs, cancer.»

In order to study gene function, the EUMODIC consortium produced mouse lines which each had a single gene removed.

«To our knowledge, our model is the first in which expression of a single gene in postnatal hair cells results in hair cell survival and hearing preservation in mice that otherwise suffer from age - related and noise - induced hearing loss,» Dr. Chen said.

With just a bit of hindbrain and a flap of ear where the head should be, the mouse pup is a freak of science — but it is also the first proof that a single gene plays an essential role in creating a head.

Single - cell mouse embryos were infected in vitro with recombinant lentiviral vectors to generate transgenic mice carrying the green fluorescent protein (GFP) gene driven by a ubiquitously expressing promoter.

A single gene appears to play a crucial role in coordinating the immune system and metabolism, and deleting the gene in mice reduces body fat and extends lifespan, according to new research by scientists at the Jean Mayer USDA Human Nutrition Research Center (USDA HNRCA) on Aging at Tufts University and Yale University School of Medicine.

He has worked in the biotech industry as a research scientist for over 11 years with a focus on emerging technologies including gene targeting in mice, molecular analysis of transgenes using GFP variants at the single cell level, and developing flow cytometry reagent kits to speed up assay development time for researchers.

A single injection of a new treatment has reduced the activity of the gene responsible for Huntington's disease for several months in a trial in mice.

A single mutation in a gene can lengthen a mouse's life by nearly a third without any noticeable harm, according to a study in today's Nature.

Using novel technologies developed at HMS, the team looked at how a single sensory experience affects gene expression in the brain by analyzing more than 114,000 individual cells in the mouse visual cortex before and after exposure to light.

The research, the cover story of this month's Science Advances, builds upon previous studies from Dr. Olson in which CRISPR - Cas9 corrected a single gene mutation that caused DMD in mice.

Our method can assess about 300 genes in a single mouse, in as little as five weeks.»

The newly published PLOS ONE study assessed the long - term efficacy of the therapy and demonstrated that a single gene therapy treatment led to prolonged production of VNA in blood and protected the mice from subsequent exposures to C. botulinum toxin for up to several months.

The Mouse Molecular Technologies team provide high - throughput genotyping and characterisation of mutant mouse strains created either by targeted embryonic stem cells (ESC) or CRISPR / Cas9 gene editing in single - cell zygMouse Molecular Technologies team provide high - throughput genotyping and characterisation of mutant mouse strains created either by targeted embryonic stem cells (ESC) or CRISPR / Cas9 gene editing in single - cell zygmouse strains created either by targeted embryonic stem cells (ESC) or CRISPR / Cas9 gene editing in single - cell zygotes.

The research goal is to use a naturally - occurring (t - complex) and / or CRISPR «gene drive» in mice to facilitate a bias of subsequent rodent generations to all be a single sex.

In findings appearing online today in Cell Stem Cell, researchers in the laboratory of Gladstone Investigator Yadong Huang, MD, PhD, describe how they transferred a single gene called Sox2 into both mouse and human skin cellIn findings appearing online today in Cell Stem Cell, researchers in the laboratory of Gladstone Investigator Yadong Huang, MD, PhD, describe how they transferred a single gene called Sox2 into both mouse and human skin cellin Cell Stem Cell, researchers in the laboratory of Gladstone Investigator Yadong Huang, MD, PhD, describe how they transferred a single gene called Sox2 into both mouse and human skin cellin the laboratory of Gladstone Investigator Yadong Huang, MD, PhD, describe how they transferred a single gene called Sox2 into both mouse and human skin cells.

The researchers chose to explore its potential in mice with a dominant cataract disorder caused by a single copy of a gene known as Crygc.

We have identified a mouse containing a single base pair deletion in the Crb1 gene.

Still, as a helpful 2009 round - up in Nature Reviews Neuroscience explains, scientists have found several single - gene knock - out mice that do better on tests of learning and memory.

With a single injection, mice showed improvements in motor coordination, weight gain and longevity compared to those without this gene therapy.

Gene targeting makes it possible to study the effects of single genes, including those that don't occur naturally in mice.

All nine of the new genes discovered had not previously been implicated in skeletal disorders and were discovered by randomly screening different strains of mice engineered such that a single gene had been inactivated in their genome.

Bethesda, Md., Wed., Oct. 26, 2016 - For the first time, National Institutes of Health (NIH) researchers have demonstrated in mice that gene therapy may be the best method for correcting the single faulty gene that causes Niemann - Pick disease, type C1 (NPC1).

For the first time, National Institutes of Health (NIH) researchers have demonstrated in mice that gene therapy may be the best method for correcting the single faulty gene that causes Niemann - Pick disease, type C1 (NPC1).