Sentences with phrase «single gene involved»

Yet for years biologists could not find a single gene involved in language.

Not exact matches

But, as journalist Steve Connor reports, the reference to editing was intentional: «Scientists have used the genome - editing technology to cure adult laboratory mice of an inherited liver disease by correcting a single «letter» of the genetic alphabet which had been mutated in a vital gene involved in liver metabolism.»

New research at the University at Buffalo reveals the first evidence that it may be possible to use a single compound to alleviate the behavioral symptoms by targeting sets of genes involved in the disease.

Scientists have shifted from studying single molecules to investigating large complexes of interacting biological macromolecules involved in processes such as metabolic pathways, gene expression, and development of disease.

«For the first time, we can predict the outcomes of modifying multiple genes involved in lignin biosynthesis, rather than working with a single gene at a time through trial and error, which is a tedious and time - consuming process,» says Jack Wang, assistant professor in NC State's College of Natural Resources and lead author of a paper about the research in Nature Communications.

It's basically a single amino - acid change in a particular gene, although newer varieties are getting a bit fancier and multiple genes may be involved.

As a postdoc in the lab of Zefeng Wang, PhD, a member of the UNC Lineberger Comprehensive Cancer Center, Choudhury stumbled upon DAZAP1 while searching for proteins involved in alternative splicing — when a single gene organizes its genetic code to create different proteins with various functions.

It is particularly useful when clinicians want to identify an illness or gene mutation involving a single patient or the patient and two or three other family members, which is the most common clinical situation for undiagnosed diseases.

While the disease is caused by a single gene mutation, the manifestation of the disease at a molecular level is nevertheless highly complex and involves multiple cellular processes.

A year ago we started thinking, why don't we select a single family with an interesting disease and see whether studying a smaller group of related individuals makes it possible to identify the genes involved in that disease.

Although mutations come in many varieties, one type, called nonsense mutations, involve the seemingly innocuous change of a single letter in the coded message — a change that causes the gene's message to prematurely read «stop.»

Other medical sequencing projects will use DNA sequencing to: discover new genes that are involved in common diseases; identify the genes responsible for dozens of relatively rare, single - gene (autosomal Mendelian) diseases; sequence all of the genes on the X chromosome from affected individuals to identify those involved in sex - linked diseases; and survey the range of variants in genes known to contribute to certain common diseases.

The UK patents relate to the CRISPR - Cas9 gene editing systems involving single - guide RNA in both non-cellular and cellular settings (UK Patent No. 2518764) and chimeric CRISPR - Cas9 systems in which the Cas9 protein is modified to provide alternative DNA - modulating activities (UK Patent No. 2537000).

This approach, which relies on a few large families, can produce misleading results for a disorder such as ADHD which may involve several genes, unlike single - gene disorders such as cystic fibrosis or Huntington's disease.

Ultimately, the combination of this new method of focusing on gene activity in single cells with other single - cell techniques involving microscopic imaging is likely to reveal the origins of developmental disorders of the brain, he added.

Kmiec noted that while some ailments, like sickle cell anemia and Huntington's disease, involve faulty DNA within a single gene, others, like Alzheimer's and heart disease, appear to involve malfunctions in multiple genes where the best option «is not really gene editing, but gene replacement.»

The paucity of single nucleotide diversity among breeds is consistent with other studies (29 — 32) and stands in stark contrast to the abundance of coding repeat variation we found in these same genes known to be involved in the developmental processes under selection in the radiation in dog breed morphologies.

This study is designed to determine the incidence of BCSL in the breed, to determine the mode of inheritance if a single gene is involved, and identify candidate genes for further investigation.

The mode of inheritance is unknown, but since the blue eyes can be single or a pair and an individual eye may be half - and - half, there probably are either more than one gene involved or there is regulatory DNA that influences the function of the gene (s) that cause this type of blue eye.

In their work on compulsive blanket and flank sucking in Dobermanns, the authors identified a single locus with genome - wide significance within the gene Cadherin 2 (cdh2), a widely expressed gene involved in pre - and post-synaptic adhesion.

The data indicate that the epigenetic response to maternal care involves not only single candidate gene promoters but includes transcriptional and intragenic sequences, as well as those residing distantly from transcription start sites.