Sentences with phrase «single gene knockouts»

Not exact matches

The power of the knockout is particularly evident with mental disorders in which a single gene has a large, obvious effect.

Workflow for targeted knockout of CD81, an endogenous gene in hiPS cells, using the Cellartis iPSC CRISPR / Cas9 Gesicle and Single - Cell Cloning System.

Cas9 nucleases from Streptococcus pyogenes (SpCas9) have been widely used for both gene knockout and knock - in at the level of single or multiple genes.

The single - gene knockout fibroblasts were successfully used for somatic cell nuclear transfer (SCNT) and resulted in live - born goats harboring biallelic mutations.

Recently, Hai et al. reported generation of single - gene knockout pigs by zygote injection of CRISPR / Cas system [13].

Unlike random mutagenesis or gene trap approaches, the propriety methodology ensures a single targeted gene deletion or knockout event.