Sentences with phrase «single genes into»

Researchers know that cells chop single genes into shorter pieces called exons, which they mix and match into one transcript for creating a protein.

Scientists had simply inserted a single gene into bacteria and coaxed them into churning out as many copies of the same protein as possible.

Not exact matches

The genes that control the sperm - making machinery are all packed into a single chromosome — the Y chromosome, the one that confers maleness.

In SIF - seq, hundreds or thousands of DNA fragments to be tested for enhancer activity are coupled to a reporter gene and targeted into a single, reproducible site in embryonic cell genomes.

By using engineered zinc - finger nucleases (ZFNs) designed to target an integrated reporter and two endogenous rat genes, Immunoglobulin M (IgM) and Rab38, we demonstrate that a single injection of DNA or messenger RNA encoding ZFNs into the one - cell rat embryo leads to a high frequency of animals carrying 25 to 100 % disruption at the target locus.

They created a single - base mutation in a spot that mutates readily, then inserted this gene into each strand.

Then they put all six genes into a single piece of DNA, so that they would all be transcribed together — and found that they could reconstitute the «3 - D printer» that assemble tubulin dimers.

Harvard Medical School researcher Melina Claussnitzer and her team found that a single variation in the FTO gene caused fat cells that would normally become healthier beige to turn into white fat cells instead.

After just a single dose, rat intestinal cells pumped out bacterial lactase for up to 6 months — showing that the gut cells had inserted the gene into their DNA and were using it to manufacture the enzyme.

These multigene interactions are subtler and knottier than the single gene drivers of diseases such as hemophilia and cystic fibrosis; spotting them calls for statistical inspiration and rigorous experiments repeated again and again to guard against introducing unproven gene tests into the clinic.

Multiple genes can feed into a single trait.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study published June 18th in the journal Cell.

However, cancer cells may instead be coaxed to turn back into normal tissue simply by reactivating a single gene, according to a study that found that restoring normal levels of a human colorectal cancer gene in mice stopped tumor growth and re-established normal intestinal function within only 4 days.

By introducing a single human gene into mice, scientists endowed the animals with full - color vision.

After the gene was duplicated — now I just mention [ed] that duplication takes place all of the time, they are common sort of genetic accidents — but after the genes were duplicated, now there was the opportunity to divide the labor that was once stored by a single gene; now divide that labor into two genes, and what happened is, a series a mutations have taken place that has optimized each role — that the regulatory sensor role of GAL3 and the enzymatic - converting role of GAL1.

«This treatment takes into account the entire genomic pattern, and shows that affecting a single gene is not enough for the treatment of pancreatic cancer or any cancer type in general,» according to Prof. Satchi - Fainaro.

Nature got a boost in the ongoing nature - versus - nurture debate this year when researchers at Emory University in Atlanta announced they could turn promiscuous male rodents into faithful cuddlers by manipulating a single gene.

Mutations generally abrogate gene function, indicating that the maize allele acts by suppressing lateral shoot development, converting grassy teosinte into slim, single - stalked modern corn and male into female reproductive structures (7).

«This methodology is very important because it allows you to very quickly integrate almost any piece of DNA in these vectors,» remarks Bellen, who says this technology also allows scientists to put single point mutations in a gene and then reinsert the gene into a genome as well as tagging a segment of DNA with fluorescent markers.

In other words, type 2 diabetes could never make it into the Finnish Disease Heritage, where a change in a single gene is decisive.

Brandis and Hughes changed many different codons and showed that changing even a single codon in the gene for this protein into any one of the alternative «synonymous» codons reduced the «fitness» of Salmonella.

This will offer us unique insights into the relationships between epigenetics and gene activity and will help us to better understand the processes that convert a single cell into the many different cell types in the body.»

A recently published study from two Iowa State University scientists shows that a gene found only in a single plant species can increase protein content when introduced into staple crops.

Scientifically, the success was the engineering of a gene cassette containing four genes for the micronutrient improvement that could be inserted into the rice genome as a single genetic locus.

Promiscuous male voles can be turned into paragons of monogamous virtue simply by increasing the expression of a single gene.

Researchers created SUSIBA2 rice by introducing a single gene from barley into common rice, resulting in a plant that can better feed its grains, stems and leaves while starving off methane - producing microbes in the soil.

Each odor - detecting neuron (referred to as olfactory sensory neuron from here on), chooses a single odorant receptor gene from a fairly large number of options that are split into class I (fish - like) and class II (terrestrial - specific) odorant receptors.

«This is the first time anyone's used a single gene to implant something as complex as a behavioral trait into another species,» says Young.

So when biologists experimenting with gene therapy want to insert a single strand into a cell, they often wind up injecting dozens.

Because of these limitations, the AAV approach is best suited for tissue culture based approaches that require modification of only a single allele of a gene, such as the introduction of heterozygous endogenous epitope tags, or the introduction of dominant mutations of a gene into the endogenous allele in cultured cells.

Optogenetics works by inserting the gene of a light - sensitive protein into live neurons, from a single cell to an entire family of them.

Research into ageing is a young field that has seen immense progress in recent years, galvanised by discoveries that single gene mutations and dietary restriction can extend healthy lifespan.

Sheng Ding and his team discovered that activating a single gene is sufficient to change skin cells into stem cells.

Those who take at trip into the workings of the genomic biology of the black - footed ferret may find that, even picking a single gene or two, they tug on the entire fabric of life.

The primary isolate env gene was exchanged into the vector in place of the HXB2 env gene, and used in a single round CAT - based virus infecti

Because disease organisms mutate quickly to overcome crop resistance controlled by single genes, researchers are rushing to identify new resistance genes and to incorporate multiple genes into high - yielding varieties, according to Ravi Singh, CIMMYT wheat scientist who participated in the reported study.

The condition is more common than muscular dystrophy and cystic fibrosis, but the development of new therapeutic concepts is hindered by the fact that unlike muscular dystrophy and cystic fibrosis, where a single mutated gene causing the disease is known, the entire human chromosome 21 (containing around 300 genes) still has to be dissected into individual gene - dose contributions to the DS symptoms.

In findings appearing online today in Cell Stem Cell, researchers in the laboratory of Gladstone Investigator Yadong Huang, MD, PhD, describe how they transferred a single gene called Sox2 into both mouse and human skin cells.

Researchers have achieved new insights into how the global control of all genes on a single chromosome can be established and maintained throughout the lifetime of an organism.Their findings about...

All genes were combined into a single file and all genes conserved among the genomes were counted, and all «unique» genes were also counted for each genome.

To develop a method of detecting associations between genes and traits that avoids these issues, Im and her colleagues integrated both transcriptome and GWAS data into a single computation framework, which they named PrediXcan.

Studying a specific type of genetic variation in the DNA sequences of wolves and domestic dogs - called Single Nucleotide Polymorphisms (SNPs)- the scientists identified the transfer of dog gene variants into wolf genomes.

Some of the team's most significant findings since 2009 were the identification of a gene mutation associated with blood cancers and the discovery of chromosomal crisis where the genome can be shattered into hundreds of fragments in a single cellular catastrophe.

These genes include the single - copy gene encoding the telomere resolvase, which converts the replicated telomeres of linear DNA into the characteristic hairpin ends of the linear chromosome and plasmids of B. burgdorferi (43).

Additionally, 2A peptides could be PCR - cloned between your genes of interest and you can then insert the whole multicistronic cassette into a backbone as a single unit.

Activating a single gene is sufficient to change skin cells into stem cells.

«It's hard to fit every single locus in the genome into one specific model of gene regulation.

By turning on a single gene, researchers can prevent skin stem cells from maturing into the three types of adult skin cells — epidermal, sebaceous and hair cells.

Might mating between an ancient human and a Neanderthal - perhaps occurring in only a single instance - have introduced a gene variant into the human population that enhanced human brain function?

Just one change to a single gene could explain why you break into a sweat trying to resist dessert, while your friend could care less about the hot lava cake topped with whipped cream.