Sentences with phrase «single key gene»

Not exact matches

«When most people think about cancer genetics, they think about single key mutations that foster tumor formation — very specific things like the BRCA genes,» said Joe R. Delaney, PhD, a fellow in the Clinical Translation program at UC San Diego Moores Cancer Center and lead author of the paper published February 15 in Nature Communications.

But hopes that ageing could be delayed by targeting a single gene or protein in a single molecular pathway have faded, as researchers have learned that the key pathways vary according to the animal.

After analyzing brain tissue samples, the researchers identified an area of the gene where a single change reduced BDNF levels in the hypothalamus, a key area that controls eating and body weight.

With the completion of the first phase of the Human Genome Project in 2000, and the advent of sequencing technologies that can detect gene variations such as single nucleotide polymorphisms (SNPs), for the first time scientists have the tools in hand to find the key immune genes and genetic networks that play roles in vaccine response.

In their new Science paper, the researchers analyzed gene expression in single cells across key developmental time points and from different regions of the brain.

Single - stranded, noncoding micro-ribonucleic acids (microRNAs), consisting of 18 - 23 nucleotides, play a key role in regulating gene expression.

The university recently received international attention after a group of 16 scientists based at the Key Laboratory of Gene Engineering published the results of a controversial experiment in which they genetically modified single - cell human embryos to repair the human β - globin (HBB) gene in a procedure aimed at preventing a serious blood disorder (www.sciencemag.org/content/348/6234/486.fuGene Engineering published the results of a controversial experiment in which they genetically modified single - cell human embryos to repair the human β - globin (HBB) gene in a procedure aimed at preventing a serious blood disorder (www.sciencemag.org/content/348/6234/486.fugene in a procedure aimed at preventing a serious blood disorder (www.sciencemag.org/content/348/6234/486.full).

«This work reveals how a single mutation in a key cardiac gene can lead to at least two forms of disease.»

However, if the purpose of such a scan is to identify candidate genes, then — as with single - gene studies — more detailed follow - up and functional validation of at least some of the key genes of interest are necessary to shore up the evidence.

The single most highly represented family of dysregulated genes was the key liver P450 cytochrome detox gene which is needed in the first of three steps for detox (30 genes in total).