The phrase
"single nucleus" means that there is only one central part in a cell, which controls all its activities.
Full definition
Production of a Quality Control Pipeline for
Single Nuclei RNA - seq and Its Application in the Analysis of Cell Type Diversity of Post-Mortem Human Brain Neocortex
From Muggleton - Harris, Pereira - Smith learned delicate techniques to fuse two cells into one, with
a single nucleus containing all of the chromosomes from both cells.
This thin film then grows outward from
a single nucleus.
They used a chemical cocktail to isolate the cells» nuclei, and placed
a single nucleus in each well of a 384 - well plate.
The control spot shows an even distribution of cytoplasmic p65 with
a single nuclei in the center of cells.