Sentences with phrase «single pharmacokinetic»
The single pharmacokinetic study published on non-concentrate naloxone showed that only 4 % of naloxone is absorbed when administered nasally.
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The Phase 1 study of ISIS - SMNRx is a single - dose, dose - escalation study designed to assess the safety, tolerability and pharmacokinetic profile of the drug in children with SMA between the ages of 2 - 14 who are medically stable.
The pharmacokinetic properties of J147 after a single dose of 20 mg / kg in mice show brain levels of about 600 nM at 2 h, over 10-fold above its EC50 in some cell culture neuroprotection assays [7], with a brain to blood ratio of approximately 0.5.
Comparison of the single dose pharmacokinetics, pharmacodynamics, and safety of two novel oral formulations of dimethandrolone undecanoate (DMAU): a potential oral, male contraceptive.
The ascending - dose, single - blind, placebo controlled, randomized trial will evaluate the safety as well as the pharmacokinetic and pharmacodynamic profile of DG041.
Due to the sex - related disparities in pharmacokinetics and bioavailability results reported by different authors (Soldin, Chung, & Mattison, 2011; Soldin & Mattison, 2009), the choice of a single genus was chosen to avoid a high dispersion in the data, and the availability of healthy young adult female volunteers for the study.
Pharmacokinetics of tramadol hydrochloride and its metabolite O - Desmethyltramadol following a single, orally administered dose in California sea lions (Zalophus californianus).
Pharmacokinetics of a single subcutaneous dose of sustained release buprenorphine in Northern elephant seals (Mirounga angustirostris).
Pharmacokinetics of a single - dose orally administered ciprofloxacin in California sea lions (Zalophus californianus).