Dr Ton added: «Plant immunity that is controlled by
a single resistance gene, on which most conventional breeding programs are based, is comparably easy to overcome by a pathogen.
And yet,
a single resistance gene can quickly lose its effectiveness.
Not exact matches
Microbes could load these donated
genes together on a
single piece of DNA, accelerating the spread of
resistance even further.
Plant breeders have discovered that a
single gene, the SUB1
gene, confers
resistance to submergence of up to 14 days.
Others might be engineered to include nutrients like beta carotene, iron, and vitamin A. Instead of one
gene to fight off insects or disease, crops will be engineered with «stacks» of
resistance genes to prevent pests from evolving
resistance to a
single approach.
Growing
resistance to malaria drugs in Southeast Asia is caused by a
single mutated
gene inside the disease - causing Plasmodium falciparum parasite, according to a study led by David Fidock, PhD, professor of microbiology & immunology and of medical sciences (in medicine) at Columbia University Medical Center.
«The bad news about our finding is that it shows that
resistance can arise through
single mutations in one
gene and pop up anywhere, at any time,» Dr. Fidock says.
The researchers, led by Dr Charles Wondji, used a wide range of methods to narrow down how the
resistance works, finding a
single mutation in the GSTe2
gene, which makes insects break down DDT so it's no longer toxic.
By adding a
single gene from wheat, researchers have created fungus - resistant trees that pass their
resistance on to their offspring and, hopefully, subsequent generations too (see «American chestnut set for genetically modified revival «-RRB-.
Companies selling Bt seeds hope to avoid that in part by designing plants that make more than one Bt toxin, but this strategy may not work if
resistance to several toxins is tied to a
single gene, says Tabashnik, who is now at the University of Arizona.
As a result, most possess only a
single disease -
resistance gene.
In a study, published in Science, they investigated a
gene region that contains a particular
single nucleotide variant associated with increased risk for developing colorectal and prostate cancers — and found that removing this region caused dramatic
resistance to tumor formation.
The most famous one is the
gene that causes sickle cell anemia: While two copies of that
gene cause a disease that's devastating in its own right, a
single copy creates a healthy child with strong malarial
resistance.
Because disease organisms mutate quickly to overcome crop
resistance controlled by
single genes, researchers are rushing to identify new
resistance genes and to incorporate multiple
genes into high - yielding varieties, according to Ravi Singh, CIMMYT wheat scientist who participated in the reported study.
Earlier cases of
resistance were largely due to mutations in
single genes — trump cards that immediately made for invincible parasites.
The nucleases were capable of pushing out an undesirable trait in a plant — such as a
gene for a chemical that acted as an environmental pollutant when consumed by livestock — and replacing it with a desirable trait, such as herbicide
resistance, in a
single shot.
To this end, we determined the susceptibility of 38 NAPCR1 isolates to ten antibiotics from seven classes using E-tests or macrodilution tests and examined 31 NAPCR1 whole - genome sequences to identify
single nucleotide polymorphisms and
genes that could explain the observed
resistance phenotypes.
No significant differences were seen between the normoxic and hypoxic anoikis - resistant populations collected from MCF7 cells and a
single significant
gene change (PIP) was seen in T47D (Table 1) suggesting that the CSC - enriched population remains virtually unchanged following hypoxic culture and the increase in MFC, HFC, and tumor initiating cells is, therefore, due to expansion of the population, perhaps by increased symmetric self - renewal of the CSC or de-differentiation of early progenitor cells, rather than simply the acquisition of anoikis
resistance in non-CSC.
The team of researchers in collaboration with Patricia Okubura, a USDA - ARS research geneticist, confirmed that
resistance was conferred by a
single gene.
Back in March of this year, however, Monsanto admitted that pink bollworms had developed
resistance to Bt cotton in the Indian state of Gujarat, in plots where the
single gene variety (Bollgard I) of the GM crop was planted.
There are
genes that confer
resistance to every
single antibiotic we use to cure gonorrhea.
There are
genes out there that confer
resistance to every
single antibiotic we use to cure gonorrhea.