Sentences with phrase «single subclone»

However, in some cases it seems that no single subclone can achieve dominance on its own.

«No single subclone seems to be capable of gaining the upper hand, leading us to wonder whether subclones might be working together in some instances.

Not exact matches

In all 7 cases, the results suggest a linear model of clonal evolution, in which progression from MDS to sAML was characterized by persistence of a single founder clone (defined by ~ 200 - 700 mutations) and the outgrowth of at least one new subclone which contained dozens or hundreds of additional mutations.

Whether identifying rare subclones missed by standard bulk sequencing, or identifying co-mutation patterns in subclones, Tapestri Single - Cell DNA Panels can be applied across a wide number of applications, including hematologic malignancies, solid tumor profiling, and genome editing programs.