Sentences with phrase «single ubiquitin»

Moffitt researchers performed molecular studies to show for the first time that SETDB1 is constitutively modified by a single ubiquitin molecule.

The addition of many ubiquitin molecules can target a protein for degradation, while the addition of a single ubiquitin molecule (monoubiquitination) can lead to activation of protein signaling pathways or target other proteins for ubiquitination.

Not exact matches

Elimination of a single amino acid — a proline — in this region abrogates VHL's ability to attach ubiquitins and thus safeguards HIF - 1.