Sentences with phrase «sites for transcription factors»

What's important about the discovery is that MER41's bits and pieces include binding sites for transcription factors involved in fighting infections.

Not exact matches

Exchange with components of a Saccharomyces cerevisiae system was undertaken to reveal the factor or factors responsible for the difference in location of the transcription start site, about 30 base pairs and 40 to 120 base pairs downstream of the TATA box in S. pombe and S. cerevisiae, respectively.

Chemistry PhD candidate Richard Li, computational nano / bio physicist Rosa Di Felice, quantum computing expert and Viterbi Professor of Engineering Daniel Lidar along with computational biologist Remo Rohs sought to apply machine learning to derive models from biological data to predict whether certain sequences of DNA represented strong or weak binding sites for binding of a particular set of transcription factors.

Retrotransposons are littered with transcription factor binding sites, which might be expected for entities that make their living by getting copied into RNA over and over again.

The variant allele disrupts predicted binding sites for two transcription factors (MEF2C and CDX2) and creates possible binding sites for at least two others.

Host proteins, including specific transcription factors with binding sites near transcription start sites, are necessary for this specificity (32 - 33).

The group of promoters, whose H3K4me3 levels were affected by combined chidamide and decitabine treatment, but not by either chidamide or decitabine treatment alone, was enriched with binding site motifs for PU.1, a transcription factor that activates gene expression during myeloid and B - cell lymphoid cell development15, 16 (Figure 5C).

ALFA compiles the current state - of - art about the annotations of DNA regulatory elements (such as transcription factor binding sites, microRNA target sites) for a better understanding of biological processes underlying rare diseases.

Johnson and Cole Labs uncover a new role for a tumor suppressor in DNA repair (11/15/16) Work from the Johnson lab previously showed that E2F1, a critical transcription factor target of the retinoblastoma (Rb) tumor suppressor protein, localizes to sites of both UV and IR induced DNA damage in a phosphorylation dependent manner.

As the target sequences for transcription factors are short, and transcription factors are tolerant of considerable variation in the sequences to which they bind, it is extremely difficult to distinguish functional binding sites in the vastness of the human genome.

These 45 variants are significantly enriched for protein - coding changes (n = 13), direct disruption of transcription - factor binding sites (n = 3), and tissue - specific epigenetic marks (n = 10), with the last category showing enrichment in specific immune cells among associations stronger in Crohn's disease and in gut mucosa among associations stronger in ulcerative colitis.

The algorithm can also accurately predict the effect of mutations on gene expression even for very low - affinity binding sites — regions in the genome where transcription factors bind to DNA, but do so in hard - to - detect ways.

Yang L, Zhou T, Dror I, Mathelier A, Wasserman WW, Gordân R, Rohs R. TFBSshape: a motif database for DNA shape features of transcription factor binding sites.