Sentences with phrase «sites on each chromosome»

The genes thought to be responsible for many of the pathologies associated with the disorder are being identified and mapped to sites on chromosome 21

While additional study is clearly needed, our current studies have clearly identified off - target disruption in two of the top 15 putative off - target sites: an extragenic site on chromosome 12 and in the metalloprotease ADAMTS17, which is not expressed in CD4 + T cells.

Not exact matches

In one experiment with human cells, a guide RNA should have led the Cas9 enzyme only to a gene on chromosome 2 (yellow bar), but it also directed the enzyme to many off - target sites (red) on several other chromosomes.

Guided by specially tailored RNA molecules, the gene for the enzyme can be inserted anywhere on the chromosomes, and it delivers an attached transgene to the site, like a locomotive pulling a freight car.

Chromosome fragile sites are regions of DNA double strand breaks on human chromosomes.

On this week's show: Building yeast chromosomes from scratch and a roundup from the daily news site

The two major advantages of this estimate are that (a) it only depends on previously discovered variable sites in higher coverage modern dogs (our genotype calling in ancient samples is likely to be much more accurate in such situations), and (b) it uses only a single chromosome from each population (which can be randomly picked), and thus does not require calling heterozygotes accurately (that is, it should not be sensitive to the lower coverage of our ancient samples).

A targeting vector was designed to insert an internal ribosome entry site (IRES), a Cre recombinase sequence, a polyA sequence, and an frt - flanked neo cassette into the 3» untranslated region (after the translational termination site) of the glutamic acid decarboxylase 2 locus (Gad2) on chromosome 2.

The most accurate epigenetic clock looks at 353 methylation sites out of millions on our chromosomes.

Mad2 and the APC / C compete for the same site on Cdc20 to ensure proper chromosome segregation % U http://jcb.rupress.org/content/early/2012/09/17/jcb.201205170.short.

Mad2 and the APC / C compete for the same site on Cdc20 to ensure proper chromosome segregation.

The exome sequences of 1,535 Kronos and 1,200 Cadenza mutants have been re-sequenced using Illumina next - generation sequencing, the raw data aligned to the IWGSC Chinese Spring chromosome arm survey sequence, mutations identified, and their effects predicted based on the protein annotation available at the Ensembl Plants archive site.

Such an allelic chromatin organization might be present at other DMRs as well, and a recent study by Schweizer et al. (2) shows that the imprinting - control region in the 5 % portion of the SNRPN gene has strong hypersensitive sites on the unmethylated maternal chromosome only.

Using an enzyme that targets some 200 sites on the X chromosomes in mosquito eggs, the team has managed to shred X chromosomes so thoroughly «that it's too much for the cell to repair,» Burt said.

At this differentially methylated imprinting - control region, we detected constitutive DNase - I hypersensitive sites (HS) and a non-nucleosomal chromatin organization on the unmethylated maternal chromosome (see contribution of S. Khosla).

Genes have pairs of alleles (one from each parent) that are located at specific sites (loci) on a chromosome.