Strikingly, we observed that induction of either ß - catenin LOF or GOF mutations in MuSCs leads to the impairment
of skeletal muscle regeneration following injury.
Differentially activated macrophages orchestrate myogenic precursor cell fate during human skeletal muscle regeneration
The aim or our team is to understand the role of the interactions myogenic cells develop with their environment in the regulation
of skeletal muscle regeneration and their impact in the pathological context of degenerating myopathies.
Myeloid HIFs are dispensable for resolution of inflammation during skeletal muscle regeneration
Results of a study conducted by researchers at the University of Pittsburgh School of Medicine and the McGowan Institute for Regenerative Medicine showed significant improvement in strength and range of motion, as well as evidence
for skeletal muscle regeneration, in 13 patients who were surgically implanted with bioscaffolds derived from pig tissue to treat muscle injuries.
Advancement of Research for Myopathies Research Grants The program's purpose is to accelerate biomedical research aimed at developing treatments for Autosomal Recessive Vacuolar or Inclusion Body Myopathies associated with GNE mutations and
skeletal muscle regeneration.
In this study, Chazaud et al., evidenced that endothelial cells (ECs) and myogenic progenitor cells (MPCs) interacted to couple myogenesis and angiogenesis during
skeletal muscle regeneration.
Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration
AMPKalpha1 regulates macrophage skewing at the time of resolution of inflammation during skeletal muscle regeneration
Montarras D, Morgan J, Collins C, et al., Direct Isolation of Satellite Cells for
Skeletal Muscle Regeneration.
His primary interest is in understanding the processes of
skeletal muscle regeneration and fibrosis, the impact of physical stress on the immune system and the preventive aspect of physical activity and exercise.
mTOR is necessary for proper satelite cell activity and
skeletal muscle regeneration (Zhang et al., 2015)