Sentences with phrase «skeletal myopathies»

Collectively, our work has led to novel pathophysiologic and therapeutic insights for diseases, such as heart failure, aortic aneurysms, diabetes, and skeletal myopathies.

We suggest these observations will have therapeutic implications for skeletal myopathies and systemic diseases such as diabetes and obesity and for the aged population, in which reduced endurance impacts mortality and activities of daily living (57); as well as societal implications in terms of altering athletic performance.

Not exact matches

Researchers who previously showed that a gene therapy treatment could save the lives of dogs with a deadly disease called myotubular myopathy — a type of muscular dystrophy that affects the skeletal muscles — have found that the therapy is long - lasting.

About six in 100,000 babies are born with centronuclear myopathy, which weakens skeletal muscles so severely that children have trouble eating and breathing and often die before age 18.

Dogs Provide Insight Into Rare Genetic Disease Centronuclear myopathy weakens skeletal muscles so severely that sufferers often die before age 18.

In his graduate research, Linsley discovered the gene Stac3 is a component of the excitation - contraction machinery in skeletal muscle and the mechanism by which mutations in that gene cause Native American Myopathy, a rare but devastating congenital disease.

Abstract Type 1 ryanodine receptor (RyR1) is preferentially expressed in skeletal muscle, and mutations in the gene have been associated with malignant hyperthermia, a pharmacogenetic disease, and with several congenital myopathies, including central core disease, multiminicore disease, centronuclear myopathy, congenital fibre type disproportion.

It is known that long - term treatment of rats with the drug causes myopathy and decreased skeletal muscle protein concentration (20,21).

Avian Chlamydiosis; Bloodborne Organisms; Disorders of the Skeletal System (Poultry); Myopathies (Poultry)