They used a neonatal mouse model with
skin barrier mutations and tried exposing its skin to food allergens like peanuts, finding the peanuts alone had no effect.
Not exact matches
Researchers said clinical evidence shows that up to 35 % of children with food allergies have atopic dermatitis, much of which is explained by at least three different gene
mutations that reduce the
skin barrier.
Infants were also screened for
mutations in the filaggrin (FLG) gene, which codes for a key
skin barrier protein.
«Scientists have found many
mutations in essential proteins that play a role in forming the
skin barrier,» explains Garden.
Genetic analysis revealed that German shepherds with certain
mutations in the PKP2 gene had a much higher risk of eczema, suggesting that low levels of the plakophilin - 2 protein break down the
skin barrier in dogs with the
mutation.