Infants were also screened for mutations in the filaggrin (FLG) gene, which codes for a key
skin barrier protein.
«This finding helps confirm that
skin barrier proteins are important in Atopic Dermatitis for people of all ancestries,» said lead study author David Margolis, MD, PhD, professor of Dermatology and Epidemiology.
Genetically engineered mice lacking three
skin barrier proteins («knock - out» mice) were used in the King's study to replicate some of the skin defects found in eczema sufferers.
Not exact matches
Filaggrin, a key
protein in
skin barrier function, is deficient in adults.
He recently has focused on a specific
skin -
barrier protein called filaggrin, which is broken down into a molecule called urocanic acid — the most potent absorber of UVB light in the
skin, according to Elias.
Eczema can result from the loss of structural
proteins in the outermost layers of the
skin, leading to a defective
skin barrier.
Normally, the
skin provides a thick protective
barrier stemming from keratin — a tough structural
protein also found in hair and fingernails.
The gene encodes a
protein called plakophilin 2, which is crucial for the formation and proper functioning of the
skin structure, suggesting an aberrant
skin barrier as a potential risk factor for atopic dermatitis.
Use high - quality collagen
protein and bone broths to help heal the gut lining and improve the strength and integrity of the
skin barrier.
«Scientists have found many mutations in essential
proteins that play a role in forming the
skin barrier,» explains Garden.
«This has an amazing technology that protects
protein and lipids in the
skin and helps keep your
barrier intact.»
Airborne pollens, molds, dust particles etc. gain entry to the
skin through a defective
skin barrier, and from there their
proteins are presented to the immune system.
The new study, published today in the journal PLoS Genetics, identifies abnormal functioning in a gene called PKP2 that encodes the plakophilin - 2
protein, which promotes and maintains a healthy
skin barrier.
Genetic analysis revealed that German shepherds with certain mutations in the PKP2 gene had a much higher risk of eczema, suggesting that low levels of the plakophilin - 2
protein break down the
skin barrier in dogs with the mutation.
The POODLE ADULT formula helps support a strong
skin barrier and a healthy coat with PINCH, high quality
proteins (including amino acids methionine and cysteine), biotin and omega 3s (EPA and DHA).