Sentences with phrase «skin cells from patients»

Even cooler, scientists are now able to «reprogram» human skin cells from patients with neurological disorders and grow them into brain cells [source: Kavli Foundation].

NYSCF Research Institute scientists in collaboration with researchers at the Icahn School of Medicine at Mount Sinai refined a technique to turn skin cells from patients...

They reprogrammed adult skin cells from patients with NOTCH1 mutations into a kind of stem cell called induced pluripotent stem cells (iPSCs).

Working at the University of California, Davis, the researchers created a new cellular model for studying Down syndrome by taking skin cells from patients with Down syndrome and inducing them into a pluripotent state.

First, the researchers took skin cells from patients and introduced genes to correct the defective mutations.

In the future, we would like to study skin cells from patients with disorders of motor neurons.

To do so, they converted skin cells from patients into so called induced pluripotent stem cells.

The researchers, led by University of California, San Diego neuroscientist Mark Tuszynski, took skin cells from the patients, grew them up in a culture dish and genetically engineered them to make human nerve growth factor (NGF).

«Use of induced pluripotent stem cell (iPSC) technology» — which involves taking skin cells from patients and reprogramming them into embryonic - like stem cells capable of turning into other specific cell types relevant for studying a particular disease — «makes it possible to model dementias that affect people later in life,» says senior study author Catherine Verfaillie of KU Leuven.

In the present study, her team took skin cells from patients with lissencephaly and turned them into iPS cells, which they then cultivated under special conditions into neuronal stem cells and neurons that are copies of those in the patients» brains.

The disease model, described in a new study by a UC San Francisco - led team, involves taking skin cells from patients with the bone disease, reprogramming them in a lab dish to their embryonic state, and deriving stem cells from them.

The two groups took skin cells from patients and transformed them into the type of brain cells that are affected by Alzheimer's.

Zheng, together with Leah Boyer, then a researcher in Gage's lab and now director of Salk's Stem Cell Core, generated diseased neurons by taking skin cells from patients with Leigh syndrome, reprogramming them into stem cells in culture and then coaxing them to develop into brain cells in a dish.

In new research, scientists reprogrammed skin cells from patients with rare blood disorders into iPSCs, highlighting the great promise of these cells in advancing understanding of those challenging diseases — and eventually in treating them.

To develop their «disease in a dish» model, the team took skin cells from patients with Allan - Herndon - Dudley syndrome and reprogrammed them into induced pluripotent stem cells, which then can be developed into any type of tissue in the body.

«In theory, we could model progression of the disease by reprogramming skin cells from patients at a range of ages, including before symptoms begin.

For instance, researchers at the Salk Institute in California have taken skin cells from a patient with the genetic disease Fanconi's anemia, often associated with leukemia.

Adding four genes to a specialized adult cell — such as a skin cell from a patient — can convert it into an iPS cell.

The team, led by Eggan and Christopher Henderson of Columbia University Medical Center, grew iPS cells by introducing the four genes used in the earlier studies into about 30,000 skin cells from the patient.

A group that included researchers at the Wellcome Trust Sanger Institute and the University of Cambridge, both in the United Kingdom, developed a possible treatment for A1ATD by first reprogramming a skin cell from a patient into iPS cells, which are embryonic - like cells that can develop into many tissue types.

First, they took adult skin cells from a patient with an HBB mutation that causes sickle cell disease.

It is now almost routine to grow skin cells from a patient with, say, a neurological disease; turn them into pluripotent cells in a Petri dish; convert the cells into nerve cells to study the disease process; and contemplate using the cells to repair the same patient's damaged brain.

Not exact matches

According to Science Daily, Dr. Nagy, senior investigator at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, there is a «new method of generating stem cells that does not require embryos as starting points and could be used to generate cells from many adult tissues such as a patient's own skin cells.»

They are also getting skin cells from glioblastoma patients to make sure the new method works for the people they hope to help, he says.

Skin cells are easy to collect from patients and share the same genetic blueprint — and disease - causing mutations — as brain cells.

And other researchers question the need to use cells from the patient's own skin.

The study, published Feb. 5 in Nature Neuroscience, showed that the patients» nerve cells — converted directly from patients» skin cells — exhibited «symptoms» of the disorder, including DNA damage, dysfunctional mitochondria and cell death.

Beginning in the 1970s, physicians learned how to harvest skin stem cells from a patient with extensive burn wounds, grow them in the laboratory, then apply the lab - grown tissue to close and protect a patient's wounds.

Scientists from the University of Cambridge's Institute for Medical Research obtained skin cells from 10 patients — seven who had various forms of inherited liver disease, and three healthy controls.

Finally, he would suck out stem - cell - rich fat from the patient's belly and inject it into a layer under the dermis to replenish the fat that keeps skin elastic and soft.

To test the platform, they obtained skin cells from consenting patients at the Center for Duchenne Muscular Dystrophy, all of whom had mutations that fell within the dystrophin gene hot spot.

The investigators obtained further evidence of the critical role of astroglial cells in Down syndrome by implanting the skin - cell derived astroglial cells from Down syndrome patients into mice.

In addition to helping understand disease by providing more powerful study models, «what this technology would allow you to do is reprogram a skin cell, for example, from a Parkinson's patient... into a pluripotent cell and then in a petri dish redirect that cell into... a neuron» to treat that patient.

Because neural crest cells can also be isolated from skin and hair follicles, OECs could potentially be grown from a patient's own cells.

Researchers can create iPSCs from a patient's blood or skin cells, and use these patient - specific cells to study diseases or even create new tissues that could be transplanted back into the patient as therapy.

The study team removed fibroblasts (skin cells) from DBA patients, and in cell cultures, using proteins called transcription factors, reprogrammed the cells into iPSCs.

Unlike the skin cells from which they originated, the human iPS cells created from FOP patients show increased cartilage formation and increased bone mineralization, two critical steps that are necessary to form mature bone.

Researchers might generate personalized brain organoids from the reprogrammed skin cells of individuals with, say, schizophrenia and test which medications work best for patients with particular genetic profiles of the illness.

Stem cell source: Obtained from skin or blood cells of patients.

Fragile skin that blisters easily: 90 percent of the patients that suffer from the skin condition recessive dystrophic epidermolysis bullosa (RDEB) develop rapidly progressing cutaneous squamous cell carcinomas, a type of skin cancer, by the age of 55.

This time, instead of using skin cells, the team reprogrammed lymphocytes (immune cells) from six entirely new bipolar patients, some of whom are known lithium responders.

The technique allows scientists to make stem cells from, for instance, a patient's skin cells.

Since the 1970s tissue engineers have been figuring out how to grow skin, bone, cartilage, and even parts of vital organs using cells harvested directly from patients.

Currently, grafts are either sheets of skin taken from a donor site on the body, or layers of cells cultured in vitro from the patient.

The bacterial peptide found to activate MS patients» T cells came from Pseudomonas aeruginosa, a common inhabitant of human skin which can infect wounds.

In fact, the new approach is similar to an established treatment for severe burns, in which sheets of healthy skin are grown from a patient's own cells and grafted over wounds.

By analyzing skin cells from achromatopsia patients and their unaffected family members, the researchers confirmed that the ATF6 mutations were interfering with the signaling pathway that regulates the unfolded protein response.

To determine whether L1CAM has a role in cancer, the researchers looked for its protein in normal skin cells, cultured noncancerous cells, and aggressive melanomas from 11 patients.

Alternative cell lines, such as induced pluripotent stem cells generated from patient skin cells, offer a more accurate window on human biology, he says.

For the first time, scientists can use skin samples from older patients to create brain cells without rolling back the youthfulness clock in the cells first.