Sentences with phrase «skin fibroblast»

Knowledgeable in starting, growing, and freezing skin fibroblast cell cultures while maintaining database of complete cell culture list.

For example the researchers used the CRE - ERT2 mouse model validated at the ICS, in which Cre function is controlled by the promoter of Atypical Notch ligand Delta - like homologue1 (Dlk1) under Tamoxifen activation, a skin fibroblast marker, to carry out temporal and tissue specific inactivation of key genes involved in skin fibroblast diversity.

The potential of iPS cells to help treat everything from damaged heart tissue to Parkinson's disease, has prompted intensive research that has looked into the use of skin fibroblast cells as an alternative to controversial embryonic stem cells.

- catenin pathway activates certain lncRNAs to directly control gene expression in skin fibroblast cells.»

The research team took skin fibroblast tissue from adult mole - rats and reprogrammed the cells to revert to pluripotent stem cells.

Using patient's own tissue and specific combination of reprogramming factors, skin fibroblasts are successfully converted to cell type that... Continue reading Breakthrough Device Looks to Heal Organs

The study carried out at the University of Eastern Finland used the induced pluripotent stem cell technology, which enables the generation of pluripotent stem cells from human skin fibroblasts.

• In March, a University of Wisconsin team reprogrammed skin fibroblasts into embryonic stem cells without incorporating the viral or other foreign DNA that can lead to complications like cancer.

Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic cells, such as skin fibroblasts, into induced pluripotent stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

Simao Cruz and colleagues report the clinical findings and the results of MRI, muscle biopsy, collagen VI expression in cultured skin fibroblasts and genetic tests of a series of patients with Bethlem myopathy.

Findings from Dr. George King's laboratory at Joslin point to novel pathways to treat skin fibroblasts from diabetes patients to improve wound healing.

Developed a novel - reprogramming paradigm for generating heart, brain and pancreatic cells directly from skin fibroblasts.

We further demonstrate that lysosomal exocytosis mediates the resealing of primary skin fibroblasts wounded during the contraction of collagen matrices.

While scientists have successfully reprogrammed different types of mouse cells (fibroblasts, liver and intestinal cells), skin fibroblasts were the only human cell type they had ever tried their hands on.

Formic acid is a product of the α - oxidation of fatty acids by human skin fibroblasts: deficiency of formic acid production in peroxisome - deficient fibroblasts

A global analysis of the microenvironment of human skin fibroblasts was carried out to reveal disease ‐ related alterations in the extracellular proteome.

Expression studies have demonstrated that in female skin fibroblasts the MAOA gene undergoes X-inactivation and shows mono - allelic expression [21].

Not exact matches

Broiled salmon is also available at many Mexican restaurants for a healthy dose of omega - 3s (one of which research suggests may help protect against UV - induced skin damage) Eicosapentaenoic acid inhibits UV - induced MMP - 1 expression in human dermal fibroblasts.

These cells, called fibroblasts, help close wounds after skin has been cut.

So Izpisúa Belmonte and his colleagues harvested fibroblasts, which are far more common than stem cells, from the skin of people with the bone marrow disease Fanconi anaemia.

To find out, John O'Neill, a biologist at the Medical Research Council's Laboratory of Molecular Biology in Cambridge, U.K., and his team studied skin cells known as fibroblasts, which are essential for wound healing.

The «target» cells on the other side of the BeWo barrier to the nanoparticles were human fibroblast cells, found in skin and connective tissue.

Fibroblasts invade the void left by a scratch and lay the foundation for new skin to grow.

These were surrounded by skin - like cells called fibroblasts, which form the heart's connective tissue.

Avivi's team has found out that fibroblast skin cells from the armpits of the rats can kill human cancer cells in a dish.

The study team removed fibroblasts (skin cells) from DBA patients, and in cell cultures, using proteins called transcription factors, reprogrammed the cells into iPSCs.

They start by harvesting skin cells known as fibroblasts and growing these in a sheet.

The researchers transplanted the cardiac fibroblasts isolated from the region of calcification under the skin of healthy mice and observed soft - tissue calcification similar to that seen in the donor mice.

For many years, tattoos were thought to work by staining fibroblast cells in the dermal layer of the skin.

Skin - producing cells called fibroblasts from the tip of an adult mouse's tail have been reprogrammed to make eggs, Japanese researchers report online October 17 in Nature.

Now Yamanaka and his colleagues report in the journal Cell that the same combination of genes induced pluripotency in commercially available human fibroblasts (connective tissue cells that play a crucial role in healing) derived from the facial skin of a 36 - year - old woman, the joint tissue of a man, aged 69, and a newborn, respectively.

- catenin pathway can cause fibroblasts to overproduce connective tissue proteins, like collagen, causing harmful skin fibrosis.

Another option is to take a skin sample, culture cells called fibroblasts and freeze them.

The findings suggest disrupting lncRNA levels could change how fibroblasts function in skin.

In contrast, tuning the skin microstructure within the 3D collagen - fibroblast matrices using the manual - casting approach is extremely challenging.»

The team studied skin cells, called dermal fibroblasts, that help hair follicles develop, wounds heal, and generally maintain the structural integrity of skin.

To make the pigmented skin constructs, the team used three different types of skin cells — keratinocytes, melanocytes, and fibroblasts — and a two - step «drop on demand» bioprinting method.

For the new study, the team used a cell - reprogramming technique (similar to those used to reprogram skin cells into stem cells) to generate human DRG - type sensory neurons from ordinary skin cells called fibroblasts.

Keratinocytes and dermal fibroblasts, which form the connective tissue in skin, responded to increased TWEAK activity by producing a number of chemoattractive and pro-inflammatory factors commonly found in atopic dermatitis and psoriasis.

The elongated fibroblasts reprogrammed to become more T - cell - like in shape and hundreds of T - cell genes were also expressed in these skin cells.

Following a cut to the skin, fibroblast cells rush to the wound and secrete a matrix that helps skin cells move into place, grow, and heal the injury.

Indeed, they were: According to the team's findings, adipose stem cells can be turned into iPS cells twice as quickly as fibroblast skin cells and with 20 times the efficiency.

Xu and his team, which includes researchers from Penn's departments of Dermatology and Biology, as well as the New Jersey Institute of Technology, started with human skin cells called dermal fibroblasts.

They then isolate the fibroblasts from skin, none of which were green fluorescent at the outset.

Similarly, biopsies are obtained from many subjects and skin cells (fibroblasts) are isolated from these specimens, dedifferentiated to iPS lines, and reprogrammed and studied as neural and glial lines in culture.

When he added all four genes, about 0.01 percent of the skin - cell fibroblasts eventually became iPS cells but about 0.2 percent of the fat stem cells did so — a 20-fold improvement in efficiency.

Using unique drug cocktails, stem cell scientist Sheng Ding, PhD, a senior investigator at the Gladstone Institutes, can transform fibroblasts (skin cells) into fully functional brain, heart, liver, and insulin - producing pancreas cells.

Unlike highly specialized skin - cell fibroblasts, these cells in the fat have a relatively wide portfolio of differentiation options — becoming fat, bone or muscle as needed.

Skin substitutes involve different cell composites, such as: fibroblasts, keratinocytes, epithelial cells and / or MSCs transplanted on membranes or with supportive matrix.

Cell Stem Cell «Recently three different studies were published demonstrating that mouse fibroblast (skin) cells can be directly reprogrammed to behave like embryonic stem cells.»