Often, hot spots may occur after a dog has been swimming in a lake or river, likely because this changes the temperature and humidity of
the skin microenvironment.
These studies reveal a crosstalk between the two conserved developmental pathways in human skin, and highlight the role of
the skin microenvironment in driving the generation of stem cells, and possibly tumor - initiating cells.
Not exact matches
Metastatic melanoma is the deadliest of the
skin cancers and the mechanisms that govern early metastatic growth and interactions of metastatic cells with the brain
microenvironment remain shrouded in mystery.
Weeraratna's team used an artificial
skin reconstruct model to recreate the interactions of melanoma cells with either a young or aged tumor
microenvironment.
The research team of Dr Bassam Janji in the Laboratory of Experimental Cancer Research at LIH's Department of Oncology is specialized in the study of the tumor
microenvironment in different types of solid tumors, including
skin cancer.
But mounting evidence implicates the immune system in the overproduction of cell - signalling molecules called cytokines, which stimulate
skin cells called keratinocytes to express genes that maintain an inflammatory
microenvironment.
The idea is to introduce a biodegradable scaffold under the
skin that temporarily creates an «infection - mimicking
microenvironment,» capable of attracting, housing, and reprogramming millions of dendritic cells over a period of several weeks.
His efforts have pioneered the use of the three - dimensional «artificial
skin» cultures to study the behavior of both tumor and normal cells that sustain tumor growth, a system known as the tumor
microenvironment.
A global analysis of the
microenvironment of human
skin fibroblasts was carried out to reveal disease ‐ related alterations in the extracellular proteome.