To save the life a young boy who lost most of his skin (left, red), researchers took a small bit of his remaining skin (gray) and grew
skin stem cells in the lab.
In September 2015, the team took a 4 - square - centimeter patch of unblistered skin from the boy's groin and grew
skin stem cells in the lab from that sample.
Not exact matches
Beginning
in the 1970s, physicians learned how to harvest
skin stem cells from a patient with extensive burn wounds, grow them
in the laboratory, then apply the
lab - grown tissue to close and protect a patient's wounds.
Thanks to crucial contributions from three young
lab members, he said, his team succeeded
in converting mature
skin cells into pluripotent
stem cells.
Zheng, together with Leah Boyer, then a researcher
in Gage's
lab and now director of Salk's
Stem Cell Core, generated diseased neurons by taking skin cells from patients with Leigh syndrome, reprogramming them into stem cells in culture and then coaxing them to develop into brain cells in a d
Stem Cell Core, generated diseased neurons by taking
skin cells from patients with Leigh syndrome, reprogramming them into
stem cells in culture and then coaxing them to develop into brain cells in a d
stem cells in culture and then coaxing them to develop into brain
cells in a dish.
The disease model, described
in a new study by a UC San Francisco - led team, involves taking
skin cells from patients with the bone disease, reprogramming them
in a
lab dish to their embryonic state, and deriving
stem cells from them.
For the purpose of additional experiments, the researchers generated myocardial
cells from embryonic
stem cells and human
skin cells,
in collaboration with the
lab headed by Prof Dr Jürgen Hescheler at the University of Cologne.
To create different
cell types
in the
lab,
stem cells must be coaxed down the road of determination — the branching paths that fetal
cells normally travel to become neurons,
skin cells, muscle
cells, or any number of other
cell types.
Then De Luca and colleagues used a retrovirus to insert a healthy copy of the LAMB3 gene into DNA
in the
lab - grown
skin stem cells.
Several types of progenitor
stem cells (purple, yellow) were present
in the
lab - grown
skin cells, along with long - lived holoclones (pink).
It is possible to force human
skin cells to turn back into embryonic
stem cells in the
lab, but this doesn't seem to be something we are able to achieve without intervention.
Both teams successfully used these to reprogramme
skin cells in a
lab dish into
cells resembling embryonic
stem cells, which have the ability to turn into any tissue of the human body.
After losing 80 percent of his
skin to a devastating genetic disease, a seven - year - old boy underwent an experimental treatment replacing his epidermis with new
skin grown
in a
lab from genetically modified
stem cells.
Multipotent
stem cells with neural crest - like properties have been identified by our
lab and others
in the dermis of human
skin.
Some researchers are using induced pluripotent
stem (iPS)
cells — tissue - specific
cells (usually
skin cells, but sometimes other tissue
cells) that are reprogrammed
in the
lab to behave like embryonic
stem cells — to grow rods and cones or RPE
cells.
In the
lab, she coaxed
skin cells into becoming induced pluripotent
stem cells, or iPS
cells.
Currently, her
lab is focused on finding drugs suitable for eliminating mammary cancer and ocular herpevirus infections
in small companion animals, and evaluating the effectiveness of
stem cell therapies for treating
skin wounds
in horses — all of which may also be used
in humans and other animals.