We know the most adverse symptoms occur in people who are genetically programmed to be
slow metabolizers of caffeine.
More than 50 percent of Americans are
slow metabolizers of caffeine, so there's a good chance you'll sleep better and feel less anxious and revved up if you stop for twenty - one days.
It turns out that your «cardiac twitch» is related to your caffeine metabolism —
slow metabolizers of caffeine have a higher risk of heart attacks if they drink more than two cups of coffee per day; however, fast metabolizers have a reduced risk of a heart attack if they have at least a cup of coffee a day.
Of course, there are potential downsides, especially if you're
a slow metabolizer of caffeine.
Not exact matches
As I wrote in my book, The Genetics
of Health people with the AA variant
of the CYP1A2 gene are fast
metabolizers, while those with the AC or CC subtypes
of the gene are
slow metabolizers.
These fast
metabolizers break down caffeine up to four times more quickly than those people who inherited one or two
of the
slow - variant version
of CYP1A2.
The same amount
of caffeine will tend to have more stimulating effect on
slow metabolizers than on fast
metabolizers.
If you have two copies
of this gene variant, you metabolize caffeine much
slower than «fast» caffeine
metabolizers.
If you know you're a
slow caffeine
metabolizer, it's safest to limit your caffeine to one cup
of coffee daily, or two at most, due to the potential for it to stay in your system longer.
Coffee is metabolized in Phase I
of the liver detoxification pathway, and some people have a harder time breaking it down — we call them «
slow metabolizers.»
Our findings show that coffee consumption increases the risk
of MI only among individuals with a
slow metabolizer genotype.