Sentences with phrase «small animal model»

Because of the lack of a small animal model for HIV transmission at the time, we decided to first try to block herpes transmission in mice.

Murine gammaherpesvirus 68 infection of IFNγ unresponsive mice: a small animal model for gammaherpesvirus - associated B - cell lymphoproliferative disease.

«The big question about why we mammals affiliate with one potential partner versus another finally has a handle we can use in a small animal model,» says Lucy Brown at the Albert Einstein College of Medicine in New York.

The ongoing Zika virus outbreak in Latin America and the Caribbean has created an urgent need for identifying small animal models as a first step toward developing vaccines and treatments to fight the infection.

The French Foundation for rare diseases (Fondation des maladies rares), in partnership with TEFOR infrastructure, launches its first call for research projects «Small animal models and rare diseases».

The Center for Predictive Medicine recognizes the challenges of translational research such as in designing and implementing high - throughput screens and assessing small molecules and potential vaccines for their efficacy in small animal models of disease.

In 2017, it will be joined by Anipath, a platform devoted to the histological analysis of small animal models including phenotyping, diagnosis of morbidity cause, in situ gene expression studies.

The core facility is a two - photon in vivo imaging platform developed at the Nonlinear bioimaging laboratory, a technique that allows for non-invasive structural and functional measurements in small animal models at different scales: from macroscopic imaging of the brain morphology to highly resolved microscopy of neuron populations, single neurons, and even subcellular structures.

I was excited about translating our promising in vitro results into therapies, but in 2001 there were still no good small animal models of HIV infection.

Not exact matches

4) Wheat germ agglutinin, a direct intestinal toxin in animal models, exerts disruptive effects on gastric, small intestinal, and colonic mucosa.

As a small local farm, Drumlin Farm models an alternative to the often inhumane treatment of factory raised animals.

The Nutritional State - structured Model (NSM) by ecologist Justin Yeakel (UC Merced), biologist Chris Kempes (Santa Fe Institute), and physicist Sidney Redner (Santa Fe Institute) incorporates body size and metabolic scaling into an extinction model where «hungry» or «full» animals, great and small, interact and procreate on a landscape with limited resouModel (NSM) by ecologist Justin Yeakel (UC Merced), biologist Chris Kempes (Santa Fe Institute), and physicist Sidney Redner (Santa Fe Institute) incorporates body size and metabolic scaling into an extinction model where «hungry» or «full» animals, great and small, interact and procreate on a landscape with limited resoumodel where «hungry» or «full» animals, great and small, interact and procreate on a landscape with limited resources.

He generates three - dimensional computer models of animals using a micro-CT scanner, which works in a similar way to a medical CT scanner but is designed for investigating small objects.

The CDC team's work combines «superb conventional epidemiology with a well - characterized animal model,» epidemiologists Barry Bloom and Peter Small write in an accompanying editorial.

Ellen Heber - Katz, a scientist at The Wistar Institute in Philadelphia, used to study autoimmunity — that was until she noticed something strange in the mice she was using to model lupus: The small holes that she had poked in their ears to distinguish the animals from one another kept closing.

Chief among the criticisms were the animal's hindlimbs, significantly smaller compared with other large predatory dinosaurs, as well as other researchers» theoretical Spinosaurus models.

With this in mind, he and Amit Kapoor, also at Columbia, set out to find a smaller animal that could serve as a model for hepatitis C.

With this in mind, Ian Lipkin and Amit Kapoorm, both at Columbia University in New York, set out to find a smaller animal that could serve as a model for hepatitis C.

In a novel animal study design that mimicked human clinical trials, researchers at University of California, San Diego School of Medicine report that long - term treatment using a small molecule drug that reduces activity of the brain's stress circuitry significantly reduces Alzheimer's disease (AD) neuropathology and prevents onset of cognitive impairment in a mouse model of the neurodegenerative condition.

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

A row of scientifically accurate models of Proboscidean heads runs along the wall in evolutionary order, including a small - trunked animal from about 25 million years ago, and the long - faced Gomphotherium, a close relative of the elephant and an ancestor of the woolly mammoth from about 5 million years ago.

They incorporated the lifecycle of phytoplankton and zooplankton — small, often microscopic animals at the bottom of the food chain — into a novel mechanistic model for assessing the global ocean carbon export.

The zebrafish's transparency, small size, and rapid reproduction make it one of the best models for studying how animals and bacteria «talk» to each other, she adds.

Though they found a few elements of the fossilized skull, the researchers chose to model the skull after a few well - preserved skulls of smaller animals related to titanosaurs, and «scaled it up to the size that this animal would be,» Norell said.

The objective is to support innovative projects dedicated to the development and the study of rare disease models using small animals (mouse model excepted) such as zebrafish, drosophila, nematode, rat and rabbit.

Arguably, the most economical and efficient strategy for development of small molecules with regenerative medicine applications is to use non-mammalian animal models for both target - and phenotype - based drug discovery.

He has also been involved in vaccine research using small and large animal models, e.g. pigs.

«This study provides proof - of - concept experiments, in large animal models, that a small, miniaturized device can be safely implanted in the brain and provide miniaturized control of the electrical activity and function of single neurons or small groups of neurons.

Phenotypic approaches screen for the effects of small molecules on an observable characteristic of an animal, tissue or cell model, typically without a priori knowledge of the target.

These are parameters that we will evaluate in a future project in a larger animal model, since small animals are difficult to handle and in several occasions tend to die within the process from stress.

Preclinical diabetes models and islet transplantation in small and large animals (including non-human-primates)

The Animal Models Core off ers BSL - 2, BSL - 3 and select agent facilities for basic and translational research for small animal stAnimal Models Core off ers BSL - 2, BSL - 3 and select agent facilities for basic and translational research for small animal stanimal studies.

Since 2006 when Biomedcode was established, we have evaluated hundreds of therapeutics including novel biologics, biosimilars, biobetters and small molecules using a unique array of animal disease models closely mimicking the complexity of human inflammatory conditions.

However, the spinal nerve L5 / 6 ligation model has not been widely utilized in mice, in part because surgery, particularly ligation of mouse L6, and behavioral testing in such small and active animals are challenging.

To build upon the encouraging early discoveries, Helmsley renewed and expanded its Crohn's funding for the Institute in 2013 to begin new work with three major aims: 1) continue studies of individual genes to determine how genetic differences between Crohn's patients and healthy individuals contribute to the disease; 2) evaluate promising small molecules in disease - relevant studies and prioritize insights from genetics to help develop novel therapeutics; and 3) begin basic experimentation in animal models with Crohn's disease to provide the data necessary to begin testing new therapies in humans.

A Models Core has a full range of ex vivo / in vivo murine, small animal and non-human primate models of inflammation and biomarker discovery, with advanced immunology and imModels Core has a full range of ex vivo / in vivo murine, small animal and non-human primate models of inflammation and biomarker discovery, with advanced immunology and immodels of inflammation and biomarker discovery, with advanced immunology and imaging.

Current work focuses on identifying novel Eph receptor - targeting agents (such as peptides and small molecules) as well as improving the existing ones in collaboration with medicinal chemists and structural biologists, and evaluating them in cell culture and in vivo animal models.

The Animal and Human Imaging Shared Resource enables Cancer Center investigators to execute high throughput, quantitative and noninvasive in vivo imaging studies on animal models, apply and validate MRI, optical, CT, PET, SPECT and ultrasound methods for noninvasive detection and characterization in small animals and incorporate emerging and clinical relevant quantitative MRI and PET protocols into Phase I, II and III clinical trials in a centralized, cost effective mAnimal and Human Imaging Shared Resource enables Cancer Center investigators to execute high throughput, quantitative and noninvasive in vivo imaging studies on animal models, apply and validate MRI, optical, CT, PET, SPECT and ultrasound methods for noninvasive detection and characterization in small animals and incorporate emerging and clinical relevant quantitative MRI and PET protocols into Phase I, II and III clinical trials in a centralized, cost effective manimal models, apply and validate MRI, optical, CT, PET, SPECT and ultrasound methods for noninvasive detection and characterization in small animals and incorporate emerging and clinical relevant quantitative MRI and PET protocols into Phase I, II and III clinical trials in a centralized, cost effective manner.

The main research activity (located in central Paris and vicinity at Orsay) regroups to date 16 technology platforms and services offering state ‐ of ‐ the - art expertise and equipment from small molecule chemistry to omcs, super-resolution microscopy, sophisticated radiation sources and various animal models, including xenografts directly derived from patients, in order to promote the best environment and support for research activities.

With this study, the scientists found that JQ1 can effectively treat severe, pre-established heart failure in both small animal and human cell models by blocking inflammation and fibrosis (scarring of the heart tissue).

CRISPR not only allows researchers to create these animals faster and more precisely than before, but also to move beyond a relatively small menagerie of standard model species — fruit flies, mice, zebrafish — to create a Noah's ark of mutant dogs, pigs, primates and more.

Thus, the analytical tools developed by the Schroeder lab to identify structures and functions of biogenic small molecules will be transferable to other animal models.

Earlier research of the flavonoids» positive effects, especially anthocyanidins, are restricted to very small studies in older individuals or animal models, but have revealed that cognitive function is improved with greater intake of foods with these compounds.

Every so often, farming processes included adding harmful toxins in herbicides and pesticides, not mentioning the feeding of animals in confined conditions which has drastically changed food production from the small local and sustainable farm model that the informed general population would want.

What is the effect of protein in animal models where aflatoxin is fed in small amounts every day?

«The dog and cat industry has long served as a model of how to provide support for animals throughout all stages and challenges of life,» says Lucas Stock, communications manager at Oxbow Animal Health based in Omaha, Neb. «Knowledge and education regarding the longevity and specific health needs of small animals has evolved considerably in recent decades and across all sectors.»

Italian Style Marchioro USA offers a wide variety of small animal cages, from mouse to ferret, from single level «starter» cages to deluxe models.

The Tru Catch Traps Model 30LTD works on cats, skunks, rabbits, and other small animals.

In the study, lead author Duncan Lascelles, CVM professor of small animal surgery and pain management, outlines an comprehensive argument for the translational power of utilizing companion animals with naturally occurring diseases as models of human conditions.

However if you have a smaller breed of rabbit and don't have much room at home then a model like the Large Indoor Rabbit HutchPawhut 4 Level Indoor Small Animal Cage Hutch is ideal.