Sentences with phrase «small animal models»

Historically, the preferred small animal model for hypertension research has been the rat.

Broadly, the scope of our capabilities include, but are not limited to: (1) determination of optimal route and dose for pathogen challenge, (2) determination of correlates of immunity, (3) standardization of animal models for use in «Proof - of - Concept» efficacy studies of candidate vaccines, therapeutics and immunotherapeutics and (5) toxicity and efficacy of candidate molecules or vaccines in small animal models of infectious disease.

The Center for Predictive Medicine recognizes the challenges of translational research such as in designing and implementing high - throughput screens and assessing small molecules and potential vaccines for their efficacy in small animal models of disease.

The ongoing Zika virus outbreak in Latin America and the Caribbean has created an urgent need for identifying small animal models as a first step toward developing vaccines and treatments to fight the infection.

But a first - ever small animal model provides a new tool to develop antiviral treatments.

In 2017, it will be joined by Anipath, a platform devoted to the histological analysis of small animal models including phenotyping, diagnosis of morbidity cause, in situ gene expression studies.

The core facility is a two - photon in vivo imaging platform developed at the Nonlinear bioimaging laboratory, a technique that allows for non-invasive structural and functional measurements in small animal models at different scales: from macroscopic imaging of the brain morphology to highly resolved microscopy of neuron populations, single neurons, and even subcellular structures.

Porter elaborates, «The use of ultrasound activated microbubbles to open clots is not new, but has been performed in smaller animal models or in limited experimental large - animal studies.

«The big question about why we mammals affiliate with one potential partner versus another finally has a handle we can use in a small animal model,» says Lucy Brown at the Albert Einstein College of Medicine in New York.