Sentences with phrase «small cell disease»

Not exact matches

In diseases such as malaria and sickle cell disease, red blood cells break down, with harmful effects on the rest of the body — particularly the lining of small blood vessels.

The Chiesi fund will consider a wide range of opportunities, from traditional small molecules and biologics, to gene therapies and cell therapies, to diagnostic and disease management technologies.

What Stephen Hawking Missed: Small Biotechs Developing Promising Cell Therapies for Devastating Disease Source: Streetwise Reports (5/2/18) In the second of a two - part series exploring the disruptive cell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and invesSmall Biotechs Developing Promising Cell Therapies for Devastating Disease Source: Streetwise Reports (5/2/18) In the second of a two - part series exploring the disruptive cell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investCell Therapies for Devastating Disease Source: Streetwise Reports (5/2/18) In the second of a two - part series exploring the disruptive cell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investcell therapy space, Maxim Group analyst Jason McCarthy takes a look at small - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and invessmall - cap companies targeting big - ticket indications and their potential to drive blockbuster value for both patients and investors.

Breastfeeding is contraindicated in infants with classic galactosemia (galactose 1 - phosphate uridyltransferase deficiency) 103; mothers who have active untreated tuberculosis disease or are human T - cell lymphotropic virus type I — or II — positive104, 105; mothers who are receiving diagnostic or therapeutic radioactive isotopes or have had exposure to radioactive materials (for as long as there is radioactivity in the milk) 106 — 108; mothers who are receiving antimetabolites or chemotherapeutic agents or a small number of other medications until they clear the milk109, 110; mothers who are using drugs of abuse («street drugs»); and mothers who have herpes simplex lesions on a breast (infant may feed from other breast if clear of lesions).

However, researchers have long thought that tumors don't release intact cells into the bloodstream until relatively late in the disease, and then only in vanishingly small numbers.

At the same time, researchers have found that much smaller protein clusters called oligomers — made of only a few copies of these proteins — can be highly toxic to motor neuron - like cells grown in the lab and thus are more likely to be the chief causes of brain - cell death in these diseases.

Now, a UCLA study has traced the Pavlovian response to a small cluster of brain cells — the same neurons that go awry during Huntington's disease, Parkinson's disease and Tourette's syndrome.

A study has traced the Pavlovian response to a small cluster of brain cells — the same neurons that go awry during Huntington's disease, Parkinson's disease and Tourette's syndrome.

In the study, exosomes, which are generated by all cells and are naturally present in blood, were modified as «iExosomes,» capable of delivering small RNA to specifically target mutant KRAS, resulting in disease suppression and increased overall survival in mouse models.

Zeroing in on the smallest parts of the brain could help researchers map the actual cells responsible for initiating disease.

By getting inside the cell and getting the body to produce intracellular proteins, we have the potential to address many diseases that today aren't druggable with small molecule drugs or biologics.

Although tau buildup is found in other brain diseases, like Alzheimer's, in CTE, the protein congregates in brain cells around small blood vessels.

Cytokines are small proteins involved in cell - to - cell interactions, whose role in triggering certain diseases is now becoming clear.

«Our research has identified a gene affecting another type of ischemic stroke, due to small vessel disease, and also suggests some genes may be associated with both ischemic and hemorrhagic stroke and may act through a novel pathway affecting pericytes, a type of cell in the wall of small arteries and capillaries.

Some of the first evidence for cancer stem cells came from studies of leukemia in the 1990s, which showed that only a small subset of the cancerous blood cells could propagate the disease in mice.

When Cas9 and the short guide RNA targeting a disease gene are delivered into cells, a specific cut is made in the genome, and the cells» DNA repair processes glue the cut back together, often deleting a small portion of the genome.

A certain cytokine, or small protein that helps cells communicate during immune responses, can control whether immune cells promote or suppress inflammatory bowel disease, a finding that could lead to new treatments, according to a study led by Georgia State University.

Small molecule drugs can be screened or designed to increase telomerase activity exclusively within stem cells for disease treatment as well as anti-aging therapies without increasing the risk of cancer.

«Many chemotherapy drugs leave a small amount of cancer stem cells that cause a renewed outbreak of the disease after a few years.

UCLA scientists have unlocked an important mechanism that allows chemotherapy - carrying nanoparticles — extremely small objects between 1 and 100 nanometers (a billionth of a meter)-- to directly access pancreatic cancer tumors, thereby improving the ability to kill cancer cells and hence leading to more effective treatment outcome of the disease.

The scientists did this by manipulating a small molecule known as sphingosine -1-phosphate (S1P), which they report is found in elevated levels in people with sickle cell disease.

The high MAO - B activity consistently observed in patients with Parkinson's disease has been proposed as a biomarker, but there has been a lack of suitable small molecule probes for MAO - B specific detection in live cells and tissues.

Parkinson's disease is a slowly progressive disease that affects a small area of cells within the mid-brain known as the substantia nigra.

Among lung cancer patients; suicide SMR was higher in males (SMR = 8.8), Asians (SMR = 13.7), widowed patients (SMR = 11.6), older patients (70 - 75 years; SMR = 12), patients with undifferentiated tumors (SMR 8.6) or small cell lung carcinoma (SCLC) histology (SMR = 11.2), patients presenting with metastatic disease (SMR = 13.9) and in patients who refused to receive surgical treatment (SMR = 13).

But if even a small number of mutant mitochondria are retained after the transfer — a common occurrence — they can outcompete healthy mitochondria in a child's cells and potentially cause the disease the therapy was designed to avoid, experiments suggest.

Now, researchers have found that a very small subset of anti-viral immune cells, transplanted along with a donor's blood stem cells, could be enough to fight and even prevent the disease caused by CMV, in research conducted in mice and published Jan 16th in the Journal of Immunology.

Now, researchers report that they've used computers to help them target a region of the virus that rarely changes, and they've designed a small protein that renders the virus unable to infect cells and cause disease, at least in mice.

His group showed that a small number of stem - cell like CD8 T cells - called «memory» cells - were enough to produce and repeatedly replenish all of the T - effector cells needed to fight the disease.

Microfluidic devices are tiny chips that can sort out disease biomarkers, cells and other small structures in samples like blood by using microscopic channels incorporated into the devices.

A reduction in the number of these cells impairs vascular stability, and leads to cerebral small vessel disease.

One option would be to shut down the expression of BCL11A, using small pieces of RNA, in blood - forming stem cells that would then be given to a person with the disease; another would be to inhibit the action of BCL11A directly using a more traditional, and possibly more practical, small - molecule drug.

Recreating a small part of the MERS virus, which has killed 76 people so far, could block it from infecting cells and spreading disease

By differentiating cells over and over under various conditions, his group intends to use them to screen for small molecules that might interfere with the disease process.

And because the body doesn't need much of the enzyme, modifying just a small fraction of the liver's cells should be enough to treat the disease.

The cells generated in the Zeng lab may not only provide a potential unlimited source for cell replacement therapy for Parkinson's disease, but also offer an unprecedented opportunity to develop screening models for assessing small molecule drugs and to clarify the mechanisms of disease.

$ 1.8 M Supports Cancer Drug Discovery on Commonly Mutated Gene New Brunswick Patch — April 5, 2016 Behavioral Scientist Shares Insights about FDA's Proposed Rule on Banning Tanning Bed Use among Minors News-Medical.net - March 19, 2016 Intervention Program Reduces Caregiver Distress during Hospitalization of Pediatric Stem Cell Transplant Patients News-Medical.net - March 9, 2016 Exploring Genomic Pathways in the Development of Ovarian Cancer GMNews.com - March 2, 2016 Differences in Type of Small Protein may further Elucidate Lung Cancer Risk in African Americans ScienceDaily.com - March 2, 2016 Study Looks at Post-Treatment Resources for Prostate Cancer Patients Transitioning to Survivorship News-Medical.net - February 11, 2016 Drawing the Line on Tanning Bed Use by Teens ScienceDaily.com - December 21, 2015 What Rutgers Study Uncovered about E-Cigarette Use NJBiz.com - December 9, 2015 Identification of Barrier that Prevents Progression of Benign Kidney Tumors to Malignant Disease MedicalNewsToday.com - November, 24, 2015 What is the Color of the Lung Cancer Ribbon?

For these purpose, we explore and validate the use of cell progenies derived from pluripotent stem cells to produce disease models in a dish, to screen for compounds (small molecules, biologicals, etc).

Scientists from the Sundrud lab have identified a normally small subset of immune cells that may play a major role in the development of Crohn's disease as well as steroid resistance associated with the disease.

By surveying gene expression in over 53,000 cells from the small intestine, researchers have created a rich reference for understanding the biology of inflammatory bowel disease and food allergies, among other conditions.

Until now, this method has not worked with the thousands of much smaller proteins, which can cause diseases if defective, that are inside cells.

Abstract: Molecular machines, much smaller than single cells, may one day be able to deliver drugs to kill cancer cells or patrol your body for signs of disease.

To better understand this complex tissues and its functions — and the diseases that affect it — a multicenter team led by researchers at the Broad Institute of MIT and Harvard and Massachusetts General Hospital has released a census of the cells that make up the lining of the small intestine, using gene expression profiles of more than 53,000 individual cells from the mouse gut or gut organoid models.

Diseases potentially amenable to convertase inhibitor therapy include diseases of excess hormone production such as ectopic peptide production in small cell carcinoma; furin inhibition would be beneficial in blocking cancer pathogenesis.

Murine gammaherpesvirus 68 infection of IFNγ unresponsive mice: a small animal model for gammaherpesvirus - associated B - cell lymphoproliferative disease.

But the mechanisms involved in most diseases are inside cells, and reaching those requires small molecules, at least for now.

The onset and progression of disease in inherited ALS is determined by the motor neurons and microglia, small immune cells in the spinal cord, which migrate through nerve tissue and remove damaged cells and debris.

Since the recent discovery of tremendous biological effects of nitric oxide, other small gaseous molecules such as carbon monoxide or hydrogen sulfide have emerged to be similarly important in cell signaling, with a great impact on pathophysiology of various diseases.

A dual yeast and human stem cell discovery platform for Parkinson's disease: Investigations in simple baker's yeast cells brought to light abnormalities in Parkinson's patient neurons and identified genes and small molecules that correct them.

Characteristic neuropathological findings were focal depletion of diffuse and neuritic plaques, but not of amyloid angiopathy, and the presence of small numbers of extremely dense (collapsed) plaques surrounded by active microglia, and multinucleated giant cells filled with dense Abeta42 and Abeta40, in addition to severe small cerebral blood vessel disease and multiple cortical hemorrhages.

My research focuses on the evolution, physiology and biochemistry of alpha crystallins, a group of small heat shock proteins that protect cells against stress and are implicated in numerous diseases such as lens cataracts, Parkinsons, Alzheimers and cancer.