Sentences with phrase «small cell lung cancer cells»

Regulation of cellular proliferation, cytoskeletal function, and signal transduction through CXCR4 and c - Kit in small cell lung cancer cells.

Scientists from the Cancer Research UK Manchester Institute, based at The University of Manchester and part of the Manchester Cancer Research Centre, teamed up with experts at AstraZeneca, as part of a collaboration agreed in 2010, to test a drug — known as AZD3965 — on small cell lung cancer cells.

Not exact matches

With lung cancer, for example, it wants to be able to resolve whether a test shows non-small-cell lung carcinoma or small cell lung carcinoma.

Non — small cell lung cancer may involve genetic aberrations that can be used to direct therapy.

«Cause of chemoresistance in small cell lung cancer discovered.»

Approximately one year after successful treatment with cytotoxic chemotherapy and radiotherapy, patients with advanced Small Cell Lung Cancer (SCLC), which primarily affects heavy smokers, generally relapse with recurrence of tumours that are resistant to further chemotherapy.

A late breaking subanalysis of the phase III CONVERT trial presented at the European Lung Cancer Conference (ELCC) shows that white blood cell boosting drugs are safe during concurrent chemo - radiotherapy of small cell lung cancer (SCLung Cancer Conference (ELCC) shows that white blood cell boosting drugs are safe during concurrent chemo - radiotherapy of small cell lung cancer (Cancer Conference (ELCC) shows that white blood cell boosting drugs are safe during concurrent chemo - radiotherapy of small cell lung cancer (SClung cancer (cancer (SCLC).

The abstract title was: Attempt to Validate Drug Repositioning for Metastatic Small Cell Lung Cancer (SCLC) Therapy Identifies Statins Associated with Survival Benefit.?

Dr. Weiss» study of pembrolizumab was presented during a session on small cell lung cancer when the theme of the conference was Science Drives Lung Cancer Advanlung cancer when the theme of the conference was Science Drives Lung Cancer Advcancer when the theme of the conference was Science Drives Lung Cancer AdvanLung Cancer AdvCancer Advances.

One, in which Dr. Weiss was the senior author, highlighted the extended survival of metastatic small cell lung cancer (SCLC) patients who received statins.

One postdoc presents data on her efforts to develop an organoid model for small - cell lung cancer; another reports progress on culturing hormone - secreting organoids from human gut tissue.

The research group plans to move forward with more - advanced technology and larger populations to investigate field cancerization in other lung cancer subtypes, such as small - cell lung cancer, in smokers and in lung cancers that develop in non-smokers.

Among lung cancer patients; suicide SMR was higher in males (SMR = 8.8), Asians (SMR = 13.7), widowed patients (SMR = 11.6), older patients (70 - 75 years; SMR = 12), patients with undifferentiated tumors (SMR 8.6) or small cell lung carcinoma (SCLC) histology (SMR = 11.2), patients presenting with metastatic disease (SMR = 13.9) and in patients who refused to receive surgical treatment (SMR = 13).

That prospect looked even more remote when Martensen's doctors discovered that he had squamous small cell lung cancer, a less common form in which the cancer cells are scaly and thin.

This new drug — AZD3965 — is currently in clinical trials, but it has not yet been tested in small cell lung cancer.»

«Our laboratory results are promising and certainly provide encouragement to test this treatment clinically in patients with small cell lung cancer.»

Researchers at Norris Cotton Cancer Center have found an antibody that may be used in future treatments for recurrent small - cell lung cancer, which currently has no effective thCancer Center have found an antibody that may be used in future treatments for recurrent small - cell lung cancer, which currently has no effective thcancer, which currently has no effective therapy.

«Antibody - targeted treatment developed for recurrent small - cell lung cancer.»

The Genes and Cancer Group at the Cancer Epigenetics and Biology Program of the IDIBELL has found that the MAX gene, which encodes a partner of the MYC oncogene, is genetically inactivated in small cell lung cCancer Group at the Cancer Epigenetics and Biology Program of the IDIBELL has found that the MAX gene, which encodes a partner of the MYC oncogene, is genetically inactivated in small cell lung cCancer Epigenetics and Biology Program of the IDIBELL has found that the MAX gene, which encodes a partner of the MYC oncogene, is genetically inactivated in small cell lung cancercancer.

Jacks» lab is now investigating the roles of genes associated with other types of lung cancer, such as small cell lung cancer.

Thoracic Oncology — Lung cancer, malignant mesothelioma, thymoma and thymic carcinoma, small cell cancer in other body sites, chest sarcomas, pulmonary carcinoid tumors, other rare thoracic cancers

Our expert lung cancer team works together to care for all types of cancer that affect the lungs and chest, including non-small cell lung cancer, small cell lung cancer, mesothelioma, and thymoma.

Sarah B. Goldberg, MD, MPH, an assistant professor of medicine at the Yale School of Medicine and Yale Cancer Center, discusses osimertinib (Tagrisso) for the treatment of patients with non — small cell lung cCancer Center, discusses osimertinib (Tagrisso) for the treatment of patients with non — small cell lung cancercancer.

The companies have launched a phase II trial of the antibody - drug conjugate, and are also testing it in other solid tumors, including ovarian and non — small - cell lung cancers.

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Itraconazole Inhibits Angiogenesis and Tumor Growth in Non — Small Cell Lung Cancer.

Management of chemotherapy - related anaemia with low - dose recombinant human erythropoietin in patients with small cell lung cancer.

Small Cell Lung Cancer (SCLC): Overexpression of CXCR4 is found in SCLC [30, 31, 37] and mediates the migration of SCLC to bone marrow along an SDF - 1 gradient [37].

A randomized, phase II trial showed improved progression - free survival in small - cell lung cancer with maintenance sunitinib vs placebo following standard chemotherapy, according to results presented at the annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago.

Navitoclax Enhances the Efficacy of Taxanes in Non — Small Cell Lung Cancer Models.

Functional expression of CXCR4 (CD184) on small - cell lung cancer cells mediates migration, integrin activation, and adhesion to stromal cells.

Phase II study of cediranib (AZD 2171), an inhibitor of the vascular endothelial growth factor receptor, for second - line therapy of small cell lung cancer (NCI # 7097).

He concluded that the improvement in progression - free survival and potential for overall survival benefit should lead to a phase III trial of this therapy option in small - cell lung cancer.

«In 100 percent of small - cell lung cancers, there is a deletion in this region of chromosome 3, very often including the HYAL2 gene,» he said.

Researchers have found that treating patients who have early stage non-small cell lung cancer with a type of radiotherapy called stereotactic body radiation therapy is associated with a small but increased risk of death from causes other than cancer.

Though commonly associated with breast cancer, HER2 mutations occur in a small proportion of non — small - cell lung cancer (NSCLC) patients.

Verma has successfully developed lentiviral vector - mediated mouse models for glioblastoma, lung adenocarcinoma and small cell lung cancer (SCLC).

The trial in small - cell lung cancer showed promise.

Fig 3 Effect of continued smoking on all cause mortality, development of a second primary, or recurrence in small cell lung cancer.

The life table analysis was based on a notional cohort of 65 year old smokers diagnosed with early stage non-small cell lung cancer or limited stage small cell lung cancer.

In both early stage non-small cell lung cancer and limited stage small cell lung cancer, we found evidence of a significant association between continued smoking and recurrence of the primary tumour; in limited stage small cell lung cancer, we found also evidence of a substantial elevation in the incidence of a second primary tumour.

Life tables were used to model five year survival for early stage non-small cell lung cancer and limited stage small cell lung cancer, using death rates for continuing smokers and quitters obtained from this review.

In small cell lung cancer, starting from bioinformatics analyses of large gene expression datasets, we clustered subsets of co-expressed gene modules, derived networks of transcription factors and simulated their dynamics using logic - based mathematical modeling.

Small cell lung cancer (SCLC) accounts for 14 percent of all lung cancers and is often rapidly resistant to chemotherapy resulting in poor clinical outcomes.

Assuming that the findings of the review reflected a causal relation between smoking cessation and risk of all cause mortality, we further investigated the data by constructing life tables for a hypothetical group of 100 patients aged 65 years with early stage lung cancer to estimate how many deaths would be prevented by smoking cessation within the non-small cell lung cancer and small cell lung cancer populations during five years.

In limited stage small cell lung cancer, an estimated 29 % of continuing smokers would survive for five years compared with 63 % of quitters on the basis of the data from this review.

The name «small cell» refers to the appearance of these lung cancer cells under a microscope.

We compared adjusted and unadjusted estimates separately for each outcome in both non-small cell and small cell lung cancer, and we tested for statistical heterogeneity by using the I2 test.

First up was Peter Campbell from Wellcome Trust Sanger Institute, who presented their first cancer genome — a small lung cancer cell line called NCI - H209.

Small - cell lung cancer, or SCLC, is one of the 2 major types of lung cancer and accounts for 10 % to 15 % of all lung cancer cases.