Sentences with phrase «small cell populations»

In addition, the method requires fewer cells than ChIP - seq, allowing investigation of processes that are limited in duration or occur in small cell populations.

First author of the paper, Dr Christian Schwartz, a European Molecular Biology Organization Long Term Fellow in Professor Fallon's group, added: «It is fascinating that a small cell population such as the ILC2s can regulate the expansion of Th2 cells and thereby shape the whole outcome of an immune response — be it beneficial in case of parasitic infections, or detrimental as in the case of allergic responses.»

Not exact matches

Since the population of cells down there is small, most people thought they would just barely be able to eke out a living, that they were organisms with very few capabilities.

Small populations of adult stem cells with somewhat limited developmental potential are responsible for the body's ability to heal injuries and replace worn out cells and tissues, and evidence is growing that rare cancer stem cells are responsible for the uncontrolled growth of some malignant tumors, including glioblastoma.

Previous studies have examined cancer stem cells (CSCs)-- small populations of cells within a tumor that are resistant to chemotherapy.

In contrast to the conversion of alpha cells, which only concerns a small fraction of the alpha cell population, the new mechanism involving delta cell fate change is a more efficient way of offsetting the loss of beta cells and thus diabetes recovery.

In the last few years, a bulk of data pointing to a small population of cells in tumors that maintain tumor growth, are particularly resistant to chemotherapy, are responsible for relapses, and develop metastases.

We don't need to use a cocktail of small molecules, growth factors or other supplements to create a population of bone cells from human pluripotent stem cells like induced pluripotent stem cells,» Varghese said.

The KU researcher said that new evidence suggests that cancer originates and progresses by a small population of cells known as cancer stem cells.

According to Semenza, «Chemotherapy may kill more than 99 percent of the cancer cells in a tumor but fail to kill a small population of cancer stem cells that are responsible for subsequent cancer relapse and metastasis.»

«By combining the genetic analysis of a small population of immune cells from healthy skin with functional experiments we were able to define two subgroups of memory immune cell and in detail decipher / dissect how these cells behave in healthy and inflamed skin,» explains Liv Eidsmo, researcher at Karolinska Institutet's Department of Medicine.

The use of cell surface markers to isolate specific cell populations is one common method for separating cells; however, isolating live cells based on their RNA expression is a powerful new way enabling the study of small cell niches in nongenetically modified animal models and human tissue.

«Previously, we thought that all of the cells in the corneal endothelium were unable to divide, but we were surprised to find this small population of dormant stem cells capable of proliferating,» said principal investigator Ula Jurkunas, M.D., a corneal and refractive surgeon at Massachusetts Eye and Ear and Associate Professor of Ophthalmology at Harvard Medical School.

Preliminary work already indicates that a small population of CD117 cells exists in the human prostate.

Most of the cells that made up the tumors were positive for CA125, but the researchers found a small population that were negative and focused on those, Janzen said.

The research group plans to move forward with more - advanced technology and larger populations to investigate field cancerization in other lung cancer subtypes, such as small - cell lung cancer, in smokers and in lung cancers that develop in non-smokers.

The study revealed that in the model system chosen by Opitz and colleagues the winning side becomes apparent at a very early stage in the growth of the population, when the numbers of cells are still relatively small.

In a culture of embryonic stem (ES) cells, a small population (around 1 %) spontaneously turns into cells that are similar to the totipotent cells of the 2 - cell stage embryo.

A Ludwig Cancer Research study published online September 14th in Nature reports a novel technique to map specific chemical (or «epigenetic») modifications made to the protein packaging of DNA using a small population of cells.

«We wanted to know if eradication of this very small population of stem cells would improve organ function, and both kidney and heart were completely protected from developing fibrosis - related complications (e.g., kidney failure and heart failure),» said Humphreys, who also heads the Onco - Nephrology Program at the Dana - Farber Cancer Institute.

The adipocyte - enriched population (gray bars) expressed small amounts of the macrophage markers (a), consistent with residual macrophage contamination seen by immunofluorescent staining of live cells (b).

Together, these results suggested that EMT contributes to the establishment of a small cell subpopulation in malignant tumors; this population is then capable of driving the regeneration of the tumor, even when the bulk tumor cell mass is destroyed by therapeutic regimens.

Small, transient populations of these totipotent cells are found in both mouse and human cultured stem cells.

Cancer, the uncontrolled growth and migration of a small population of cells within a given tissue, is one of the leading causes of death in the United States in older adults.

Small populations of immature nerve cells are found in the adult mammalian brain, a process called neurogenesis.

In fact, 88 % of the barcodes within the resistant populations were shared by at least one other replicate; prior to treatment, there are small (previously undetectable) populations of cancer cells that are resistant to drug treatment and that these are selected for during the treatment process.

Such performance - enhancing alterations will include reprogramming using non-integrating vectors or small molecules, the identification of the specific cell within the CS populations which provides therapeutic benefit, and the long - term consequences of CS cell transplantation.

Assuming that the findings of the review reflected a causal relation between smoking cessation and risk of all cause mortality, we further investigated the data by constructing life tables for a hypothetical group of 100 patients aged 65 years with early stage lung cancer to estimate how many deaths would be prevented by smoking cessation within the non-small cell lung cancer and small cell lung cancer populations during five years.

Many in vivo processes, including morphogenesis or tumour maturation, involve small populations of cells within a spatially restricted region.

Microchimerism is the presence of small populations of genetically disparate cells within a host as a result of transfusion or transplacental trafficking during pregnancy, and may influence immune tolerance in the recipient.

Additional wells containing cells from the negative sort population were cultured as above and after 17 days, pebble - like clusters of small cells were excised and transferred to ENStem - A neural progenitor media (cat.

Because of small sample size, the changes in tumor - initiating cell number were not significant (P > 0.05), but these data are supportive of the in vitro findings and suggest that hypoxia may have a positive effect on the tumor - initiating cell population in ER - α — positive breast cancers and a negative effect in ER - α — negative tumors.

In the LOW and NEG populations, very few cells were capable of forming stem cell colonies; most formed small colonies that were negative for GCTM - 2.

At 13 weeks, two distinct CD68 - positive cell populations were observed, one type was small and non-pigmented (Fig. 8C) and the other consisted of large highly pigmented cells (Fig. 8 D).

Our work indicates that only a small fraction of the population resides at the top of the hierarchy, that lineage priming (co-expression of stem cell and lineage specific genes) characterizes pluripotent stem cell populations, and that extrinsic signaling pathways are upstream of transcription factor networks that control pluripotency.

The group, led by scientists at Harvard Medical School and including Shultz, found a small population of leukemia cells that survive treatment, which they called «persister» cells.

In the case of ER - α - negative cells, however, there is a small but significant decrease in three genes; PTTG1, JAG1 and KI67 (Table 1) suggesting that the population is altered in hypoxia.

Smithies sequentially divided a population of 4400 cells into smaller and smaller pools, tracking the ones that contained pieces of DNA with diagnostic features of both the donor and recipient molecules.