Together, these results suggested that EMT contributes to the establishment of
a small cell subpopulation in malignant tumors; this population is then capable of driving the regeneration of the tumor, even when the bulk tumor cell mass is destroyed by therapeutic regimens.
Not exact matches
Only a
small subpopulation of
cells are capable of picking up DNA, a state known as «competence,» at any given time, even when the
cells are genetically identical and grown under the same conditions.
In our study, we found that the emergence of a
small non-adherent
subpopulation (approximately 1 %) survived after the first hypoxia / reoxygenation cycle and speculate that cyclic exposures of hypoxia and reoxygenation may select for the stem - like
subpopulation with the ability to overcome replication arrest whereas the majority of non-adherent
cells can not.
Importantly, these
cells expressed CD45, with
smaller subpopulations expressing the important hematopoietic markers CD117 and Sca - 1, suggesting that these
cells may have the potential to populate bone marrow and eventually replenish senescent peripheral blood hematopoietic
cells.
Fluorescence activated
cell sorting (FACS) analysis of HUF1
cells stained with the SSEA3 / 488 antibody complex, revealed a larger
subpopulation of
cells with little or no SSEA3 expression and a
smaller subpopulation with detectable SSEA3 expression (Figure 2B).