Sentences with phrase «small changes in methylation»
• CpG methylation status quantification PyroMark ID provides highly reproducible quantification of methylation frequencies in individual consecutive CpG sites, enabling accurate measurement of even small changes in methylation levels that are associated with deregulation of gene expression and tumorigenesis.
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Various previous studies had shown that epigenetic remodeling of DNA by methylation or demethylation led to changes located in synapses, where one neuron communicates with another by chemical or electrical signals sent across a small gap.
These assays make it possible to detect even small changes in DNA methylation, making them useful in the hunt for new drugs to reverse the effects of repeat expansion.
Rather, the findings suggest that methylation status may be a byproduct of other changes, such as alterations in proteins associated with the DNA, or even of inheritance via small molecules of RNA.
They also support the existence of four related subtypes based on the patterns of DNA methylation — a chemical reaction in which a small molecule called a methyl group is added to DNA, changing the activity of individual genes.